Bulletin of Pharmaceutical Sciences. Assiut · Published 2026-07-31 · DOI 10.21608/bfsa.2026.494437.3144
Hassina Meguellati, Somia Saad, Saida Ouafi, Lilya Harchaoui, Nadjette Djemouai
This study evaluated the polyphenolic content and anti-inflammatory and hypoglycemic activities of the mother plant and callus cultures of Teucrium polium L. subsp. geyrii Maire from Algeria. The mother plant and calli aged 2–12 months were analysed for total polyphenolic content and profiled by high-performance liquid chromatography. Anti-inflammatory activity was assessed using the carrageenan-induced paw oedema model, and hypoglycemic effects of the mother plant and 12‑month‑old callus infusions were evaluated by normoglycaemia and oral glucose tolerance tests. The highest polyphenolic content was observed in 8‑month‑old calli (2.54 ± 0.02 mg of gallic acid equivalent per g of dry matter). Callus infusions showed stronger inhibition of carrageenan induced paw oedema and more effectively attenuated the peak of glucose induced hyperglycaemia. These findings suggest that the richer profiles of flavones–flavonols and phenolic acids in callus contribute to their enhanced anti-inflammatory and hypoglycemic potential, thereby supporting the traditional use of T. polium in local medicine.
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Meguellati, H., Saad, S., Ouafi, S., et al. (2026). PHYTOCHEMICAL PROFILE, ANTI-INFLAMMATORY AND HYPOGLYCEMIC ACTIVITIES OF TEUCRIUM POLIUM L. SUBSP. GEYRII MAIRE: COMPARISON OF MOTHER PLANT AND CALLUS CULTURES. Bulletin of Pharmaceutical Sciences. Assiut. https://doi.org/10.21608/bfsa.2026.494437.3144