Bulletin of Pharmaceutical Sciences. Assiut · Published 2026-07-21 · DOI 10.21608/bfsa.2026.506160.3198
zainab khayoon abdlsahib, Maan Al-Nuaim, Khulood H. Oudah
Acute and chronic wounds continue to be a significant clinical challenge, necessitating advanced therapeutic platforms that can both facilitate localized and regulated drug administration and promote tissue healing. Hydrogel-based wound dressings have become a versatile biomaterial owing to their tunable physicochemical characteristics and capability to encapsulate a variety of therapeutic compounds. This review examines the structure-function interactions controlling the performance of hydrogel wound dressings,with a focus on the categorization of natural,synthetic, and hybrid hydrogel systems. Furthermore, drug-loading strategies and the basic mechanisms governing drug release are critically analyzed to emphasize their impact on treatment efficacy. This paper offers a thorough framework for the logical design of next-generation wound dressings by linking hydrogel composition and structural features with drug delivery behavior. In order to direct the creation of more potent and therapeutically applicable hydrogel-based treatment systems, future prospects and present difficulties are also examined. These findings provide a foundation for future development of improved wound healing platforms.
Abstract from DOAJ. Public domain (CC0 1.0).
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abdlsahib, z., Al-Nuaim, M., Oudah, K. (2026). Structure–Function Relationships in Polymeric Hydrogels for Wound Healing Drug Delivery: Classification, Drug Loading Strategies, and Controlled Release Mechanisms. Bulletin of Pharmaceutical Sciences. Assiut. https://doi.org/10.21608/bfsa.2026.506160.3198