Targeted degradation of P-TEFb via MDM2 substrate substitution collapses oncogenic transcriptional programs in MDM2-amplified cancers

Cell Death and Disease · Published 2026-08-01 · DOI 10.1038/s41419-026-09134-w

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Authors (15)

Ye Chen, Long Xie, Xian Guan, Xingze Huang, Jiangyu Liu, Zhipeng Zhu, Yuanfang Wu, Hanjun Guo, Lin Ma, Ying Zhang, Jiawei Zhou, Suya Zheng, Ruhong Zhou, Xin Han, Liang Xu

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Year

2026

Citation

Chen, Y., Xie, L., Guan, X., et al. (2026). Targeted degradation of P-TEFb via MDM2 substrate substitution collapses oncogenic transcriptional programs in MDM2-amplified cancers. Cell Death and Disease. https://doi.org/10.1038/s41419-026-09134-w

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