The PLAU-ITGB1-TGF-β axis orchestrates spatiotemporal reprogramming of fibroblasts at the invasive front to drive dual immunosuppressive niche and immunotherapy resistance in oral squamous cell carcinoma

Cell Death and Disease · Published 2026-07-16 · DOI 10.1038/s41419-026-09110-4

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Authors (9)

Yili Xiong, Shaopeng Liu, Lianyu Zhao, Xinze Liu, Hanzhi Zhang, Haoran Wang, Dongsheng Zhang, Changlong Wang, Haiwei Wu

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Publication details

Year

2026

Citation

Xiong, Y., Liu, S., Zhao, L., et al. (2026). The PLAU-ITGB1-TGF-β axis orchestrates spatiotemporal reprogramming of fibroblasts at the invasive front to drive dual immunosuppressive niche and immunotherapy resistance in oral squamous cell carcinoma. Cell Death and Disease. https://doi.org/10.1038/s41419-026-09110-4

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