AARS1-catalyzed H4K12 lactylation promotes HCC resistance to targeted therapy by activating RAPGEF3-RAP1 signaling

Cell Death and Disease · Published 2026-07-21 · DOI 10.1038/s41419-026-09011-6

Free full text

Authors (14)

Tanlun Zeng, Wanwan Zhu, Guanqun Sun, Tengjiao Wang, Chenna Liu, Guanghui Hu, Junyu Liu, Pengyun Ling, Li Wang, Chang Fan, Terence Kin Wah Lee, Jianru Xiao, Xijun Liang, Jin Ding

Abstract

PubPorta does not have an abstract for this article yet.

Read the article at the publisher →

Publication details

Year

2026

Citation

Zeng, T., Zhu, W., Sun, G., et al. (2026). AARS1-catalyzed H4K12 lactylation promotes HCC resistance to targeted therapy by activating RAPGEF3-RAP1 signaling. Cell Death and Disease. https://doi.org/10.1038/s41419-026-09011-6

Related articles

• Single-cell profiling uncovers a rare mesenchymal-like urothelial state associated with sarcomatoid bladder cancer · Cell Death and Disease · 2026 · Same journal
• BAP1 deficiency-induced SKA3 promotes clear cell renal cell carcinoma malignant progression by regulating chromosomal instability · Cell Death and Disease · 2026 · Same journal
• Tubular tRF‑1:30‑Gln‑CTG‑4 attenuates tubulointerstitial fibrosis by mitigating FBXO7-mediated mitophagy defect in diabetic kidney disease · Cell Death and Disease · 2026 · Same journal
• MARCKS as a mediator and target for pathological tunneling nanotubes between patient-derived glioblastoma cells and astrocytes · Cell Death and Disease · 2026 · Same journal
• The PLAU-ITGB1-TGF-β axis orchestrates spatiotemporal reprogramming of fibroblasts at the invasive front to drive dual immunosuppressive niche and immunotherapy resistance in oral squamous cell carcinoma · Cell Death and Disease · 2026 · Same journal
• Mycobacterium tuberculosis infects human peripheral hematopoietic multipotent progenitors and promotes their myeloid differentiation in vitro · Cell Death and Disease · 2026 · Same journal
• Targeted degradation of P-TEFb via MDM2 substrate substitution collapses oncogenic transcriptional programs in MDM2-amplified cancers · Cell Death and Disease · 2026 · Same journal
• SLC25A20 promotes tumor growth by reprogramming energy metabolism in lung adenocarcinoma · Cell Death and Disease · 2026 · Same journal
• Caspase-3 regulates RNA splicing and mitochondrial dynamics in microglia during Parkinson’s disease · Cell Death and Disease · 2026 · Same journal
• MAP2K6 reprograms NAD+ metabolism via the HMGA1–NAMPT axis to sensitize ovarian cancer cells to PARP inhibition · Cell Death and Disease · 2026 · Same journal