Cardiovascular Therapy and Prevention (Russian Federation) · Published 2026-04-29 · DOI 10.15829/1728-8800-2026-4776
Aim. To characterize the cardiometabolic profile, intake rate and effectiveness of lipid-lowering therapy (LLT) in liver transplant recipients.Material and methods. This cross-sectional observational study was conducted, analyzing retrospective and current clinical data from patients who had undergone liver transplantation and were referred by a hepatologist for cardiologist consultation. The study included 74 subjects aged 61 (56-65) years (men, 60,8%). The period after liver transplantation was 2,8 (1,1-7,6) years. Cardiometabolic risk factors for atherosclerosis, laboratory and imaging data, and medications were analyzed.Results. A high prevalence of following cardiometabolic risk factors was identified: atherogenic dyslipidemia (91,9%), hypertension (87,8%), carbohydrate metabolism disorders (58,1%), including type 2 diabetes (50,0%), and abdominal obesity (78,4%). Mixed hyperlipidemia was the predominant lipid metabolism disorder (48,6%), followed by pure hypercholesterolemia (31,1%) and pure hypertriglyceridemia (8,1%). Hypoalphacholesterolemia was detected in 4,1%. One in five patients with hyperlipidemia (21,5%) had severe hypercholesterolemia (low-density lipoprotein cholesterol >4,9 mmol/L). Despite the fact that 95,9% of patients had high or very high cardiovascular risk (CVR), only 9,5% received LLT associated with a reduction in CVR. Only 2 patients (2,7%) achieved target LDL cholesterol levels.Conclusion. Liver transplant recipients referred to a cardiologist have a high prevalence of cardiometabolic risk factors, and the dyslipidemia pattern is characterized by a predominance of mixed hyperlipidemia. A discrepancy was identified between high CVR and the extremely low proportion of individuals taking pathogenetic hormonal therapy, necessitating an optimized interdisciplinary approach to the management of these patients.
Abstract from DOAJ. Public domain (CC0 1.0).
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