Research map: Delivery platforms for in vivo CAR-T engineering

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Papers in this map

  1. Lipid nanoparticles for mRNA delivery · Xucheng Hou · 2021 · 4010 citations · Cited by this paper
  2. In vivo CAR-T therapy: The shift from ex vivo culturing to direct in situ immune reprogramming · Janani Gopalakrishnan · 2026 · Cites this paper
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  8. Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery · Romain Zufferey · 1998 · 1834 citations · Cited by this paper
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  10. CAR T cells produced in vivo to treat cardiac injury · Joel G. Rurik · 2022 · 1357 citations · Cited by this paper
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  12. Engineering adeno-associated virus vectors for gene therapy · Chengwen Li · 2020 · 1209 citations · Cited by this paper
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  14. Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia · Bianca Santomasso · 2018 · 954 citations · Cited by this paper
  15. Envafolimab – novel anti-PD-1/PD-L1 antibody in cancer treatment · 2026 · Related
  16. Decade-long leukaemia remissions with persistence of CD4+ CAR T cells · Jan Joseph Melenhorst · 2022 · 952 citations · Cited by this paper
  17. In vivo CAR cell therapy: from bench to bedside · 2025 · Related
  18. In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers · Tyrel T. Smith · 2017 · 788 citations · Cited by this paper
  19. From Ex Vivo to In Vivo : Advances in Lentiviral Vector Engineering for CAR-T Therapy · 2026 · Related
  20. Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis · DM McCarty · 2001 · 738 citations · Cited by this paper
  21. In vivo CAR-T cell engineering: concept, research progress, potential challenges and enhancement strategies · 2025 · Related
  22. N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice · Oliwia Andries · 2015 · 709 citations · Cited by this paper
  23. Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins · Samagya Banskota · 2022 · 673 citations · Cited by this paper
  24. EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus · Oscar A Negrete · 2005 · 584 citations · Cited by this paper
  25. CD19: a biomarker for B cell development, lymphoma diagnosis and therapy · Kemeng Wang · 2012 · 577 citations · Cited by this paper
  26. In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo · Neha N. Parayath · 2020 · 444 citations · Cited by this paper
  27. Immunogenicity and toxicity of AAV gene therapy · Hildegund C.J. Ertl · 2022 · 401 citations · Cited by this paper
  28. Mutational Analysis of the Adeno-Associated Virus Type 2 (AAV2) Capsid Gene and Construction of AAV2 Vectors with Altered Tropism · Pei Wu · 2000 · 396 citations · Cited by this paper
  29. CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential · Choong‐Hyun Koh · 2023 · 326 citations · Cited by this paper
  30. In vivo CAR T cell generation to treat cancer and autoimmune disease · Theresa Hunter · 2025 · 323 citations · Cited by this paper
  31. Erythrocyte‐Inspired Delivery Systems · Che‐Ming Jack Hu · 2012 · 310 citations · Cited by this paper
  32. In vivo human T cell engineering with enveloped delivery vehicles · Jennifer R. Hamilton · 2024 · 266 citations · Cited by this paper
  33. In Vivo mRNA CAR T Cell Engineering via Targeted Ionizable Lipid Nanoparticles with Extrahepatic Tropism · Margaret M. Billingsley · 2023 · 265 citations · Cited by this paper
  34. Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo · Meirui An · 2024 · 258 citations · Cited by this paper
  35. Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein · Jovan Nikolić · 2018 · 253 citations · Cited by this paper
  36. Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma · Eugenia Zah · 2020 · 233 citations · Cited by this paper
  37. Targeted Cell Entry of Lentiviral Vectors · Sabrina Funke · 2008 · 220 citations · Cited by this paper
  38. In Vivo Generation of CAR T Cells Selectively in Human CD4+ Lymphocytes · Shiwani Agarwal · 2020 · 192 citations · Cited by this paper
  39. Displaying High-affinity Ligands on Adeno-associated Viral Vectors Enables Tumor Cell-specific and Safe Gene Transfer · Robert C. Münch · 2012 · 187 citations · Cited by this paper

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