Case Reports in Neurology · Published 2026-07-27 · DOI 10.1159/000553626
Fadel Alqatati, Rowan Mesilhy, Mohammad Ghabashneh, Kholoud Riyad Jaber, Noora Al-Abdulla, Amin S. Sanosi, Shibu Kandalam Parampil T
Introduction: Facial diplegia is an uncommon regional variant of Guillain-Barre syndrome (GBS). It may initially resemble acute cerebrovascular disease when facial weakness appears unilateral or central in pattern. Case Presentation: A 48-year-old Sri Lankan man with untreated hypertension, obesity, and newly recognized diabetes presented approximately 18 hours after onset of slurred speech and persistent left facial weakness. Initial examination suggested a left central facial palsy, although incomplete left eye closure was also present. Non-contrast computed tomography and same-day brain magnetic resonance imaging with angiography, performed approximately 25 hours after symptom onset, showed no acute infarction, hemorrhage, vascular occlusion, dissection, or significant stenosis. Over the next 48 hours, facial weakness progressed to bilateral lower motor neuron facial palsy with mild dysphagia and weak gag reflex, while limb strength remained preserved. Cerebrospinal fluid showed albuminocytologic dissociation. Dedicated contrast-enhanced magnetic resonance imaging of the internal auditory canals showed no facial nerve enhancement; bilateral linear enhancement represented vascular enhancement. Electrodiagnostic testing showed facial motor terminal latency abnormalities, prolonged bilateral blink reflex responses, and facial muscle EMG abnormalities supportive of a facial diplegia GBS variant. Campylobacter testing and anti-ganglioside antibody testing were not performed. He received intravenous immunoglobulin 0.4 g/kg/day for 5 days and gradually improved. Conclusion: Facial diplegia GBS may initially trigger an acute stroke evaluation when early facial weakness appears unilateral or central. Repeated neurological examination, cerebrospinal fluid analysis, and neurophysiology are essential when persistent symptoms and negative neuroimaging argue against a vascular syndrome.
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Alqatati, F., Mesilhy, R., Ghabashneh, M., et al. (2026). Facial Diplegia Guillain-Barre Syndrome Variant Initially Presenting as a Stroke Mimic: Evolution from Unilateral Central-Appearing Facial Weakness to Bilateral Facial Palsy - A Case Report. Case Reports in Neurology. https://doi.org/10.1159/000553626