Case Reports in Neurology · Published 2026-06-22 · DOI 10.1159/000552699
Zexing Li, Xiaolei Zhang
: Introduction:Neonatal Fc receptor (FcRn) antagonists can improve autoimmune diseases such as myasthenia gravis by rapidly and selectively reducing serum IgG levels, and they hold potential for broader applications in other autoimmune disorders. Case Report:We report a 32-year-old female admitted with psychiatric and behavioral abnormalities, who tested positive for anti-NMDA receptor antibodies indicative of autoimmune encephalitis. Despite first-line therapy with corticosteroids and intravenous immunoglobulin (IVIG),her cognitive dysfunction progressively worsened, ultimately rendering her unable to communicate.Following four administrations of efgartigimod, the patient exhibited rapid and marked clinical improvement. Conclusion:Highlighting the potential of FcRn antagonists as an additional therapeutic option in clinical practice.
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Li, Z., Zhang, X. (2026). Efgartigimod for Anti-NMDA Receptor Encephalitis:A Case Report and Literature Review. Case Reports in Neurology. https://doi.org/10.1159/000552699