Case Reports in Neurology · Published 2026-02-09 · DOI 10.1159/000550438
<p>Introduction: The pathophysiological relationship between migraine and transient global amnesia (TGA) remains unclear. We present a case of TGA occurring temporally with a migraine attack and review the existing literature on this potential association, sometimes termed “migramnesia.” Case Presentation: A 58-year-old man with a history of episodic migraine with aura experienced a severe typical migraine headache. Approximately 3 h after onset, he awoke with profound anterograde and retrograde amnesia lasting 3 h, meeting clinical criteria for TGA. He had no recollection of the amnestic episode or the preceding headache. Brain MRI was unremarkable. Conclusion: This case adds to the limited number of reports describing a temporal link between migraine and TGA events. A review of the literature reveals conflicting evidence regarding migraine as a risk factor for TGA recurrence. While our case and some studies suggest a plausible association, the evidence is inconsistent. This case highlights the need for further research, including rigorous prospective studies and analyses of potential migraine-related subgroups within TGA populations, to clarify any underlying pathophysiological connections. </p>
Abstract from DOAJ. Public domain (CC0 1.0).
Read the article at the publisher →