Medical Journal of Dr. D.Y. Patil Vidyapeeth · Published 2026-07-01 · DOI 10.4103/mjdrdypu.mjdrdypu_536_25
Surendra K. Sethi, Manoj K. Jain, Sandeep Sharma, Hemraj Tungria, Mridula Sharma, Abhay K. Lodhi
Background and Aims: Modified electroconvulsive therapy (MECT) is associated with acute hyperdynamic response which depends upon the anesthetic agent used. This study was conducted to compare the effectiveness of dexmedetomidine 0.5 and 1.0 µg/kg) with ketamine-propofol combination in patients undergoing MECT. Material and Methods: One hundred eleven patients of either sex aged 18-60 years with American Society of Anesthesiologists (ASA) Physical Status (PS) I or II were included in this study who were randomly allocated into three groups with 37 patients each. Patients received saline infusion i.e., normal saline (NS) (100 ml), dexmedetomidine (0.5 µg/kg) in 100ml NS and dexmedetomidine (1.0 µg/kg) in 100ml NS over 10 min followed by ketamine (0.5 mg/kg) and propofol (0.5 mg/kg) in Group C, Group D1 and Group D2, respectively. The primary outcome measure was to assess hemodynamic changes while secondary outcome measures were to compare the seizure duration, recovery profile, patient satisfaction and side effects. Results: A statistically significant difference was noted in mean heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) at all time intervals till 60 min among three groups, (P < 0.01). A statistically significant reduction in mean HR, SBP, DBP and MAP was noted in Group D2 in comparison to Group C and Group D1 that remained significantly lower from its baseline value at all time intervals, (P < 0.05). Conclusion: Although both doses of dexmedetomidine (0.5 µg/kg and 1.0 µg/kg) are safe and effective but dexmedetomidine (1.0 µg/kg) seems to be more effective as an adjunct with ketamine-propofol combination for modified ECT.
Abstract from DOAJ. Public domain (CC0 1.0).
Read the article at the publisher →
Sethi, S., Jain, M., Sharma, S., et al. (2026). Comparison of Effectiveness of Two Different Doses of Dexmedetomidine with Ketamine-propofol Combination for Hemodynamic Changes, Seizure Duration and Recovery Profile in Patients Undergoing Modified Electroconvulsive Therapy: A Randomized Double-blind Control Study. Medical Journal of Dr. D.Y. Patil Vidyapeeth. https://doi.org/10.4103/mjdrdypu.mjdrdypu_536_25