Research map: Hepatocyte MLKL drives obesity-driven hepatocellular carcinoma progression via mitochondrial dysfunction independent of necroptosis in MASLD

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  1. Molecular mechanisms of necroptosis: an ordered cellular explosion · Peter Vandenabeele · 2010 · 2405 citations · Cited by this paper
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  15. Apoptosis and necroptosis in the liver: a matter of life and death · Robert F. Schwabe · 2018 · 594 citations · Cited by this paper
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  17. Pathogenesis of Nonalcoholic Steatohepatitis: An Overview · Gopanandan Parthasarathy · 2020 · 429 citations · Cited by this paper
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  19. MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation · Seongmin Yoon · 2017 · 381 citations · Cited by this paper
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  22. Metabolic dysfunction-associated steatotic liver disease in adults · Daniel Q. Huang · 2025 · 286 citations · Cited by this paper
  23. Mitochondrial fission-induced mtDNA stress promotes tumor-associated macrophage infiltration and HCC progression · Dengke Bao · 2019 · 245 citations · Cited by this paper
  24. Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis · Marta B. Afonso · 2015 · 222 citations · Cited by this paper
  25. Necroptosis contributes to chronic inflammation and fibrosis in aging liver · Sabira Mohammed · 2021 · 196 citations · Cited by this paper
  26. MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcohol-associated fatty liver and steatohepatitis · Xiaoqin Wu · 2020 · 186 citations · Cited by this paper
  27. Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease · Amine Majdi · 2019 · 150 citations · Cited by this paper
  28. Sublethal necroptosis signaling promotes inflammation and liver cancer · Mihael Vucur · 2023 · 146 citations · Cited by this paper
  29. GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues · Eliana Guerriero · 2015 · 128 citations · Cited by this paper
  30. Loss of MLKL (Mixed Lineage Kinase Domain-Like Protein) Decreases Necrotic Core but Increases Macrophage Lipid Accumulation in Atherosclerosis · Adil Rasheed · 2020 · 72 citations · Cited by this paper
  31. Epigenetic Silencing of RIPK3 in Hepatocytes Prevents MLKL-mediated Necroptosis From Contributing to Liver Pathologies · Simon Preston · 2022 · 72 citations · Cited by this paper
  32. Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation · Ren Guo · 2022 · 71 citations · Cited by this paper
  33. Obesity, non-alcoholic fatty liver disease and hepatocellular carcinoma: current status and therapeutic targets · Yinshuang Chen · 2023 · 59 citations · Cited by this paper
  34. Differential role of MLKL in alcohol-associated and non–alcohol-associated fatty liver diseases in mice and humans · Tatsunori Miyata · 2021 · 47 citations · Cited by this paper
  35. MASLD in children: integrating epidemiological trends with mechanistic and translational advances · Jeffrey B. Schwimmer · 2025 · 46 citations · Cited by this paper
  36. Impact of glutathione peroxidase 4 on cell proliferation, angiogenesis and cytokine production in hepatocellular carcinoma · Nataliya Rohr‐Udilova · 2018 · 45 citations · Cited by this paper
  37. MLKL deficiency attenuated hepatocyte oxidative DNA damage by activating mitophagy to suppress macrophage cGAS-STING signaling during liver ischemia and reperfusion injury · Jian Xu · 2023 · 41 citations · Cited by this paper
  38. Inflammation in MASLD progression and cancer · Yeon Soo Kim · 2025 · 40 citations · Cited by this paper
  39. Necroptosis in Nonalcoholic Steatohepatitis · Jérémie Gautheron · 2015 · 35 citations · Cited by this paper

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