Research map: Regulation of bone immunity by metal ions: a review of mechanisms and application progress

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Papers in this map

  1. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems · Hiroshi Takayanagi · 2007 · 1881 citations · Cited by this paper
  2. A review of soluble mediator and cytokine networks linking combination immunotherapy, tumor microenvironment remodeling and skeletal muscle dysfunction · 2026 · Related
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  5. OSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism · Matthew C. Walsh · 2005 · 735 citations · Cited by this paper
  6. HIF-1α-centered metabolic reprogramming in osteoarthritis: cell type-specific effects and intercellular crosstalk among chondrocytes, BMSCs, and macrophages · 2026 · Related
  7. Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond · Matthew C. Walsh · 2014 · 608 citations · Cited by this paper
  8. Mechanisms of osteoclast activation in inflammatory bone loss in rheumatoid arthritis · 2025 · Related
  9. Differential regulation of iron homeostasis during human macrophage polarized activation · Stefania Recalcati · 2009 · 446 citations · Cited by this paper
  10. Acquired immune-mediated thrombotic thrombocytopenic purpura with severe cholestatic liver injury and reversible acute kidney injury after ivonescimab-containing chemoimmunotherapy: a case report and literature review · 2026 · Related
  11. TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration · Wei Qiao · 2021 · 405 citations · Cited by this paper
  12. Lipoprotein (a) fuels EV71 replication by activating p38 MAPK-autophagy axis · 2026 · Related
  13. Treg cells suppress osteoclast formation: A new link between the immune system and bone · Mario M. Zaiss · 2007 · 388 citations · Cited by this paper
  14. Delivery platforms for in vivo CAR-T engineering · 2026 · Related
  15. IL-17-producing γδ T cells enhance bone regeneration · T. Ono · 2016 · 374 citations · Cited by this paper
  16. Distinct osteoclastogenic potential of granulocyte-macrophage colony-stimulating factor-induced monocyte subsets · 2025 · Related
  17. The Role of Calcium–Calcineurin–NFAT Signaling Pathway in Health and Autoimmune Diseases · Yune‐Jung Park · 2020 · 350 citations · Cited by this paper
  18. Metallothionein's role in oxidative stress: A pathway to innovative treatments · 2026 · Related
  19. Iron overloaded polarizes macrophage to proinflammation phenotype through ROS /acetyl‐p53 pathway · Yun Zhou · 2018 · 349 citations · Cited by this paper
  20. Multiple Roles for Chemokines in Neutrophil Biology · Arianna Capucetti · 2020 · 285 citations · Cited by this paper
  21. The Role of the Immune Microenvironment in Bone Regeneration · Ning Yang · 2021 · 243 citations · Cited by this paper
  22. Osteoimmunology in Bone Fracture Healing · T. Ono · 2017 · 223 citations · Cited by this paper
  23. Bioactive glasses incorporating less-common ions to improve biological and physical properties · Usanee Pantulap · 2021 · 215 citations · Cited by this paper
  24. Macrophage Polarization and the Regulation of Bone Immunity in Bone Homeostasis · Kangyi Hu · 2023 · 189 citations · Cited by this paper
  25. Immunomodulatory strategies for bone regeneration: A review from the perspective of disease types · Ni Su · 2022 · 179 citations · Cited by this paper
  26. Cerium–Luteolin Nanocomplexes in Managing Inflammation-Related Diseases by Antioxidant and Immunoregulation · Jiake Gu · 2024 · 175 citations · Cited by this paper
  27. Zn/Sr dual ions-collagen co-assembly hydroxyapatite enhances bone regeneration through procedural osteo-immunomodulation and osteogenesis · Zhenyu Zhong · 2021 · 162 citations · Cited by this paper
  28. Effect of mesenchymal stem cell‐derived exosomes on the induction of mouse tolerogenic dendritic cells · Mehri Shahir · 2020 · 161 citations · Cited by this paper
  29. Regulation of extracellular bioactive cations in bone tissue microenvironment induces favorable osteoimmune conditions to accelerate in situ bone regeneration · Zhengjie Lin · 2021 · 155 citations · Cited by this paper
  30. Immunoporosis: Role of immune system in the pathophysiology of different types of osteoporosis · Weidong Zhang · 2022 · 142 citations · Cited by this paper
  31. Role of adrenergic receptor signalling in neuroimmune communication · Sushanta Chhatar · 2021 · 134 citations · Cited by this paper
  32. Strontium Functionalized in Biomaterials for Bone Tissue Engineering: A Prominent Role in Osteoimmunomodulation · Jiaqian You · 2022 · 132 citations · Cited by this paper
  33. Osteoinduction and osteoimmunology: Emerging concepts · Richard J. Miron · 2023 · 129 citations · Cited by this paper
  34. Relationship between copper and immunity: The potential role of copper in tumor immunity · Fu Cheng · 2022 · 127 citations · Cited by this paper
  35. Inflammation: The Cause of All Diseases · Vivek P. Chavda · 2024 · 112 citations · Cited by this paper
  36. Manganese-Based Immunostimulatory Metal–Organic Framework Activates the cGAS-STING Pathway for Cancer Metalloimmunotherapy · Sui-Juan Zheng · 2023 · 109 citations · Cited by this paper
  37. Sustained zinc release in cooperation with CaP scaffold promoted bone regeneration via directing stem cell fate and triggering a pro-healing immune stimuli · Xin Huang · 2021 · 107 citations · Cited by this paper
  38. Macrophage polarization in cancer and beyond: from inflammatory signaling pathways to potential therapeutic strategies · Xiao Bai · 2025 · 107 citations · Cited by this paper
  39. Development of degradable magnesium-based metal implants and their function in promoting bone metabolism (A review) · Zhengming Shan · 2022 · 90 citations · Cited by this paper

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