Research map: Dual Modulation of Prostaglandin E2 Receptors EP3 and EP4 Protects β-Cell Mass in a Model of Aggressive Autoimmune Inflammation

Back to the article

Papers in this map

  1. Fiji: an open-source platform for biological-image analysis · Johannes Schindelin · 2012 · 73297 citations · Cited by this paper
  2. GIP Acutely Blunts Insulin- and GLP-1–Induced Muscle Microvascular Perfusion · 2026 · Related
  3. CellProfiler 4: improvements in speed, utility and usability · David R. Stirling · 2021 · 2316 citations · Cited by this paper
  4. 1314-OR: Allogeneic Islets Are Rejected by Diabetic NOD Mice while Allogeneic Neo-Islets, 3D Organoids of Islet and Mesenchymal Stromal Cells, Durably Cure Their Type 1 Diabetes without Antirejection Drugs: Mechanisms · 2026 · Related
  5. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion · Françis Rodier · 2009 · 2244 citations · Cited by this paper
  6. 1295-OR: Safety and Efficacy Study of a Needle-Free Intradermal Glucose Sensor with Activity and Sleep Tracking · 2026 · Related
  7. Sensitive red protein calcium indicators for imaging neural activity · Hod Dana · 2016 · 1162 citations · Cited by this paper
  8. 1278-OR: IGFBP7 Blockade Protects from Diabetic Cardiomyopathy · 2026 · Related
  9. Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription · H.-C. Huang · 2002 · 1040 citations · Cited by this paper
  10. 1289-OR: Effect of Different Treatment Durations of Sodium–Glucose Cotransporter 2 Inhibitor on Cardiovascular Outcomes in Patients with Type 2 Diabetes: A Target Trial Emulation Study · 2026 · Related
  11. Prostaglandin E2 Induces FOXP3 Gene Expression and T Regulatory Cell Function in Human CD4+ T Cells · Felicita E. Baratelli · 2005 · 576 citations · Cited by this paper
  12. 1342-OR: CGM Data Provides Weekly Insulin Efsitora Dose Guidance Equivalent to the Current Standard of FBG and Hypoglycemia Events for T2D Insulin Naïve Adults: A Retrospective Analysis · 2026 · Related
  13. Inactivation of specific β cell transcription factors in type 2 diabetes · Shuangli Guo · 2013 · 523 citations · Cited by this paper
  14. The Mechanism of TNF-α Combined With High Glucose in Regulating Calnexin Aggravates Endoplasmic Reticulum Stress in Endothelial Cell Injury of Diabetic Retinopathy · 2026 · Related
  15. Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors · Kohichi Kawahara · 2014 · 496 citations · Cited by this paper
  16. Adipose Tissue Overexpression of Nicotinamide Phosphoribosyltransferase Prevents Metabolic Dysfunction in Obese Mice via Extracellular Vesicles · 2026 · Related
  17. Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling · Katia Boniface · 2009 · 483 citations · Cited by this paper
  18. 1316-OR: Prevention of Cellular Senescence and EMT Enables Expansion of Human Pluripotent Stem Cell–Derived Pancreatic Endoderm Cells · 2026 · Related
  19. Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes · Cristina Aguayo‐Mazzucato · 2019 · 472 citations · Cited by this paper
  20. Effects of Pharmacological GIP Infusion on Insulin, Glucagon, and Cardiovascular Responses During Hyperglycemia in Type 2 Diabetes · 2026 · Related
  21. Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes · Peter J. Thompson · 2019 · 359 citations · Cited by this paper
  22. Fourth-Generation Epac-Based FRET Sensors for cAMP Feature Exceptional Brightness, Photostability and Dynamic Range: Characterization of Dedicated Sensors for FLIM, for Ratiometry and with High Affinity · Jeffrey B. Klarenbeek · 2015 · 334 citations · Cited by this paper
  23. Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases · Kyoshiro Tsuge · 2019 · 278 citations · Cited by this paper
  24. Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions · Mohammed Bensellam · 2017 · 253 citations · Cited by this paper
  25. PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A–SIK–CRTC3 Pathway · Kirsty F. MacKenzie · 2012 · 250 citations · Cited by this paper
  26. How Does Type 1 Diabetes Develop? · Mark A. Atkinson · 2011 · 235 citations · Cited by this paper
  27. Oxidative Stress-mediated, Post-translational Loss of MafA Protein as a Contributing Mechanism to Loss of Insulin Gene Expression in Glucotoxic Beta Cells · Jamie S. Harmon · 2005 · 234 citations · Cited by this paper
  28. Cytokine production by islets in health and diabetes: cellular origin, regulation and function · Marc Yves Donath · 2010 · 228 citations · Cited by this paper
  29. Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy. · Eduard Montanya · 2000 · 220 citations · Cited by this paper
  30. β Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice · Jinxiu Rui · 2017 · 215 citations · Cited by this paper
  31. Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells · Lars Groth Grunnet · 2009 · 210 citations · Cited by this paper
  32. Anti‐suppressor effect of cyclophosphamide on the development of spontaneous diabetes in nod mice · Reiko Yasunami · 1988 · 196 citations · Cited by this paper
  33. Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse. · Séamus Sreenan · 1999 · 194 citations · Cited by this paper
  34. Cyclophosphamide-Induced Type-1 Diabetes in the NOD Mouse Is Associated with a Reduction of CD4+CD25+Foxp3+ Regulatory T Cells · Sven Brode · 2006 · 184 citations · Cited by this paper
  35. Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway · Barak Blum · 2014 · 141 citations · Cited by this paper
  36. Prostaglandin E2 Receptor, EP3, Is Induced in Diabetic Islets and Negatively Regulates Glucose- and Hormone-Stimulated Insulin Secretion · Michelle E. Kimple · 2013 · 123 citations · Cited by this paper
  37. Cyclophosphamide-Induced Diabetes in NOD/WEHI Mice: Evidence for Suppression in Spontaneous Autoimmune Diabetes Mellitus · Brett Charlton · 1989 · 122 citations · Cited by this paper
  38. Prostaglandin E2 promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase · Chengcan Yao · 2013 · 121 citations · Cited by this paper
  39. β-Cell Proliferation, but Not Neogenesis, Following 60% Partial Pancreatectomy Is Impaired in the Absence of FoxM1 · Amanda Ackermann Misfeldt · 2008 · 116 citations · Cited by this paper

Source: OpenAlex (CC0)