Research map: Repurposing Ribavirin for Oncology: Integrating Metabolism, Signaling, and Translational Control

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Papers in this map

  1. Targeting PI3K signalling in cancer: opportunities, challenges and limitations · Jeffrey A. Engelman · 2009 · 2481 citations · Cited by this paper
  2. DSP-2342, a novel 5-hydroxytryptamine 2A/7 receptor antagonist, has therapeutic potential for behavioral and psychological symptoms of dementia · 2026 · Related
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  5. Design, synthesis, and broad spectrum antiviral activity of 1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides · Joseph T. Witkowski · 1972 · 472 citations · Cited by this paper
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  11. Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin · Sarit E. Assouline · 2009 · 316 citations · Cited by this paper
  12. Preclinical pharmacology of N-pyrrolidino “nitazene” opioids appearing in nonmedical drug markets · 2026 · Related
  13. Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap · Alex Kentsis · 2004 · 307 citations · Cited by this paper
  14. Modulation of morphine tolerance and dependence by pyrroloquinoline quinone in mice: Insights into mechanistic bridge from N-methyl-D-aspartate receptors-calcium/calmodulin-dependent protein kinase II signaling to oxidative neuroinflammation · 2026 · Related
  15. mRNA cap regulation in mammalian cell function and fate · Alison Galloway · 2018 · 254 citations · Cited by this paper
  16. Comparative analysis of ligand binding affinities and functional profiles at recombinant human β-adrenergic receptor subtypes 1, 2, and 3 · 2026 · Related
  17. Management of Respiratory Viral Infections in Hematopoietic Cell Transplant Recipients and Patients With Hematologic Malignancies · Roy F. Chemaly · 2014 · 230 citations · Cited by this paper
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  19. Signalling to eIF4E in cancer · Nadeem Siddiqui · 2015 · 226 citations · Cited by this paper
  20. The Impact of ARL13B Regulation on IMPDH-Based Cytoophidia Formation and PC-3 Cells’ Proliferation and Migration · 2025 · Related
  21. Induction of Cytoplasmic Rods and Rings Structures by Inhibition of the CTP and GTP Synthetic Pathway in Mammalian Cells · Wendy C. Carcamo · 2011 · 213 citations · Cited by this paper
  22. The structure of inosine 5′-monophosphate dehydrogenase and the design of novel inhibitors · Michael D. Sintchak · 2000 · 199 citations · Cited by this paper
  23. The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation · Hiba Ahmad Zahreddine · 2014 · 185 citations · Cited by this paper
  24. Guanosine and its role in neuropathologies · Luis E.B. Bettio · 2016 · 162 citations · Cited by this paper
  25. Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond? · Katherine L. B. Borden · 2010 · 148 citations · Cited by this paper
  26. Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery · Qingning Shu · 2007 · 146 citations · Cited by this paper
  27. CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation · Masahiro Shuda · 2015 · 143 citations · Cited by this paper
  28. The metabolism of ribavirin in erythrocytes and nucleated cells · Theodore Page · 1990 · 143 citations · Cited by this paper
  29. Ribavirin Treatment Effects on Breast Cancers Overexpressing eIF4E, a Biomarker with Prognostic Specificity for Luminal B-Type Breast Cancer · Filippa Pettersson · 2011 · 131 citations · Cited by this paper
  30. Molecular Pathways: The eIF4F Translation Initiation Complex—New Opportunities for Cancer Treatment · Hélène Malka-Mahieu · 2016 · 109 citations · Cited by this paper
  31. Further evidence that ribavirin interacts with eIF4E · Alex Kentsis · 2005 · 98 citations · Cited by this paper
  32. Ribavirin revisited in the era of direct‐acting antiviral therapy for hepatitis C virus infection · Jordan J. Feld · 2016 · 97 citations · Cited by this paper
  33. Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogs. Synthesis, structure, and interactions with IMP dehydrogenase · Gulilat Gebeyehu · 1985 · 93 citations · Cited by this paper
  34. Phosphorylation of the mRNA cap-binding protein eIF4E and cancer · Xiaotong Yang · 2020 · 90 citations · Cited by this paper
  35. Action of the active metabolites of tiazofurin and ribavirin on purified IMP dehydrogenase · Yasukazu Yamada · 1988 · 84 citations · Cited by this paper
  36. Genetic and Pharmacologic Inhibition of eIF4E Reduces Breast Cancer Cell Migration, Invasion, and Metastasis · Filippa Pettersson · 2015 · 81 citations · Cited by this paper
  37. Pleiotropic mechanisms of ribavirin antiviral activities · Zhi Hong · 2002 · 80 citations · Cited by this paper
  38. The Use of Ribavirin as an Anticancer Therapeutic: Will It Go Viral? · Joshua Casaos · 2019 · 72 citations · Cited by this paper
  39. AMPK–a key factor in crosstalk between tumor cell energy metabolism and immune microenvironment? · Na Wang · 2024 · 72 citations · Cited by this paper

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