Research map: Routes to colorectal cancer in Lynch syndrome: a decade of molecular and clinical insights converging on Schrödinger’s cat

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  1. A genetic model for colorectal tumorigenesis · Eric R. Fearon · 1990 · 12236 citations · Cited by this paper
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  11. Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer · Heikki Järvinen · 2000 · 1350 citations · Cited by this paper
  12. Homozygous TP53 alterations: a case of a biallelic splice variant and a brief review of the literature · 2026 · Related
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  15. Milestones of Lynch syndrome: 1895–2015 · Henry T. Lynch · 2015 · 838 citations · Cited by this paper
  16. A computational model for investigating the evolution of colonic crypts during Lynch syndrome carcinogenesis · 2021 · Related
  17. Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1 · Marjolijn J. L. Ligtenberg · 2008 · 832 citations · Cited by this paper
  18. When screentime fails: initiative to improve completion of hereditary cancer genetic testing after telemedicine counseling · 2026 · Related
  19. The landscape of somatic mutation in normal colorectal epithelial cells · Henry Lee-Six · 2019 · 796 citations · Cited by this paper
  20. Incidences of colorectal adenomas and cancers under colonoscopy surveillance suggest an accelerated “Big Bang” pathway to CRC in three of the four Lynch syndromes · 2024 · Related
  21. Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database · Mev Dominguez–Valentin · 2019 · 682 citations · Cited by this paper
  22. Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline · Cesare Hassan · 2013 · 565 citations · Cited by this paper
  23. Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database · Pål Møller · 2015 · 559 citations · Cited by this paper
  24. Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer) · Hans F. A. Vasen · 2007 · 557 citations · Cited by this paper
  25. Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer · Aung Ko Win · 2016 · 544 citations · Cited by this paper
  26. Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial · John Burn · 2020 · 433 citations · Cited by this paper
  27. The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade · Cristina M Albuquerque · 2002 · 394 citations · Cited by this paper
  28. Germline Genetic Features of Young Individuals With Colorectal Cancer · Elena M. Stoffel · 2017 · 338 citations · Cited by this paper
  29. Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer · Akseli Hemminki · 1994 · 330 citations · Cited by this paper
  30. Genotype‐phenotype correlation of CTNNB1 mutations reveals different ß‐catenin activity associated with liver tumor progression · Sandra Rebouissou · 2016 · 330 citations · Cited by this paper
  31. European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender · Toni T. Seppälä · 2020 · 287 citations · Cited by this paper
  32. The Immune Biology of Microsatellite-Unstable Cancer · Matthias Kloor · 2016 · 258 citations · Cited by this paper
  33. The role of mismatch repair gene defects in the development of adenomas in patients with HNPCC · Andrea E. van der Meulen‐de Jong · 2003 · 218 citations · Cited by this paper
  34. Three molecular pathways model colorectal carcinogenesis in L ynch syndrome · Aysel Ahadova · 2018 · 203 citations · Cited by this paper
  35. Surveillance for Hereditary Nonpolyposis Colorectal Cancer · Wouter H. de Vos tot Nederveen Cappel · 2002 · 189 citations · Cited by this paper
  36. Smad4-Mediated Signaling Inhibits Intestinal Neoplasia by Inhibiting Expression of β-Catenin · Tanner J. Freeman · 2011 · 187 citations · Cited by this paper
  37. Prevalence of mismatch repair-deficient crypt foci in Lynch syndrome: a pathological study · Matthias Kloor · 2012 · 180 citations · Cited by this paper
  38. Efficacy of Annual Colonoscopic Surveillance in Individuals With Hereditary Nonpolyposis Colorectal Cancer · Christoph Engel · 2009 · 177 citations · Cited by this paper
  39. No Difference in Colorectal Cancer Incidence or Stage at Detection by Colonoscopy Among 3 Countries With Different Lynch Syndrome Surveillance Policies · Christoph Engel · 2018 · 157 citations · Cited by this paper

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