Research map: RADX protects against intestinal inflammation by restraining IFI16-mediated innate immunity

Back to the article

Papers in this map

  1. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies · Siew C. Ng · 2017 · 6162 citations · Cited by this paper
  2. Mitochondrial activity promotes neutrophil degranulation and endothelial dysfunction in systemic infections · 2026 · Related
  3. Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease · Luke Jostins · 2012 · 4925 citations · Cited by this paper
  4. Impaired gephyrin G-domain trimerization and phase separation in a patient with developmental epileptic encephalopathy · 2026 · Related
  5. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice · Isao Okayasu · 1990 · 2433 citations · Cited by this paper
  6. Neoantigens and shared MICB α3 antigen dual-targeted vaccine generates potent antitumor immunity · 2026 · Related
  7. Chemically induced mouse models of acute and chronic intestinal inflammation · Stefan J. Wirtz · 2017 · 1626 citations · Cited by this paper
  8. Patient-derived resources for decoding and targeting brain metastases ecosystems · 2026 · Related
  9. DNA double-strand break repair-pathway choice in somatic mammalian cells · Ralph Scully · 2019 · 1581 citations · Cited by this paper
  10. Loss of mitochondrial DNA helicase in retinal macroglia drives neovascular retinopathy · 2026 · Related
  11. ESPGHAN Revised Porto Criteria for the Diagnosis of Inflammatory Bowel Disease in Children and Adolescents · Arie Levine · 2013 · 1417 citations · Cited by this paper
  12. CCDC174 deficiency impaired human fertility by affecting the alternative splicing of maternal mRNAs · 2026 · Related
  13. The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer · Tuo Li · 2018 · 1332 citations · Cited by this paper
  14. β-hydroxybutyrate restores social deficits by suppressing HDAC9 in the ACC of Shank3B-deficient mice · 2026 · Related
  15. Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease · Matthias Friedrich · 2019 · 784 citations · Cited by this paper
  16. Targeted enzymatic therapy for coeliac disease · 2026 · Related
  17. Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells · Ralph Zellweger · 2015 · 723 citations · Cited by this paper
  18. Experimental models for intestinal host-microbe interactions · 2026 · Related
  19. Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage · Gillian Dunphy · 2018 · 681 citations · Cited by this paper
  20. Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor · Tengchuan Jin · 2012 · 579 citations · Cited by this paper
  21. Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis · Yoshitami Hashimoto · 2010 · 578 citations · Cited by this paper
  22. An Overview of the Molecular Mechanisms of Recombinational DNA Repair · Stephen C. Kowalczykowski · 2015 · 511 citations · Cited by this paper
  23. Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn’s Disease · Vanessa Mitsialis · 2020 · 371 citations · Cited by this paper
  24. The TNBS-induced colitis animal model: An overview · Efstathios Antoniou · 2016 · 351 citations · Cited by this paper
  25. Somatic inflammatory gene mutations in human ulcerative colitis epithelium · Kosaku Nanki · 2019 · 339 citations · Cited by this paper
  26. Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways · Bing Huang · 2019 · 327 citations · Cited by this paper
  27. End Resection at Double-Strand Breaks: Mechanism and Regulation · Lorraine S. Symington · 2014 · 300 citations · Cited by this paper
  28. Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2 · Fumiko Esashi · 2007 · 289 citations · Cited by this paper
  29. Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis · Nobuyuki Kakiuchi · 2019 · 262 citations · Cited by this paper
  30. Interaction with the BRCA2 C terminus protects RAD51–DNA filaments from disassembly by BRC repeats · Owen Richard Davies · 2007 · 238 citations · Cited by this paper
  31. Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies · Jodie Ouahed · 2019 · 231 citations · Cited by this paper
  32. Somatic Evolution in Non-neoplastic IBD-Affected Colon · Sigurgeir Ólafsson · 2020 · 216 citations · Cited by this paper
  33. RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks · Huzefa Dungrawala · 2017 · 213 citations · Cited by this paper
  34. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells · Brian Budke · 2012 · 186 citations · Cited by this paper
  35. The genetic background of inflammatory bowel disease: from correlation to causality · Werna T. Uniken Venema · 2016 · 126 citations · Cited by this paper
  36. RADX Modulates RAD51 Activity to Control Replication Fork Protection · Kamakoti P. Bhat · 2018 · 112 citations · Cited by this paper
  37. The value of experimental models of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases · Vassilis Valatas · 2013 · 105 citations · Cited by this paper
  38. The ZATT-TOP2A-PICH Axis Drives Extensive Replication Fork Reversal to Promote Genome Stability · Tian Tian · 2020 · 88 citations · Cited by this paper
  39. DNA Damage and Oxidative DNA Damage in Inflammatory Bowel Disease · Cristiana Costa Pereira · 2016 · 67 citations · Cited by this paper

Source: OpenAlex (CC0)