Research map: Beyond necroptosis: structural determinants, context-dependent non-canonical functions, and precision therapeutic targeting of RIPK3

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Papers in this map

  1. Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis · Kim I. Newton · 2014 · 704 citations · Cited by this paper
  2. Genetic polymorphisms of drug-metabolizing cytochromes P450 and flavin-containing monooxygenases in dogs and pigs inform the prediction of drug metabolism and toxicity in humans and other animal species · Yasuhiro Uno · 2026 · Related
  3. RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL · Kate E. Lawlor · 2015 · 657 citations · Cited by this paper
  4. Targeting RIPK1 for the treatment of depression: From neuroinflammation to synaptic plasticity · 2026 · Related
  5. ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis · Ting Zhang · 2022 · 431 citations · Cited by this paper
  6. BiP-engaging xanthones from the mangosteen (Garcinia mangostana) induce androgen receptor degradation in prostate cancer cells · 2026 · Related
  7. DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death · Roshan J. Thapa · 2016 · 423 citations · Cited by this paper
  8. Advanced therapy medicinal products for local treatment using new delivery methods · 2026 · Related
  9. RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus · Shoko Nogusa · 2016 · 379 citations · Cited by this paper
  10. RIPK3 Inhibition Mitigates Denervated Muscle Atrophy via NOX4‐Mediated Mitochondrial Restoration and Inflammation Suppression · 2026 · Related
  11. RIPK1 and RIPK3: critical regulators of inflammation and cell death · Kim I. Newton · 2015 · 373 citations · Cited by this paper
  12. CerS2/ceramide C24:1/ROCK2 signaling-mediated angiogenesis protects against ischemic brain injury in mice · 2026 · Related
  13. The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex · Miguel Mompeán · 2018 · 355 citations · Cited by this paper
  14. Core genes drive treatment resistance in triple-negative breast cancer: characteristics, mechanisms, intervention strategies · 2026 · Related
  15. The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons · Brian P. Daniels · 2019 · 327 citations · Cited by this paper
  16. HDAC1-mediated PKM2 delactylation modification regulates CIRP-induced angiogenesis in rheumatoid arthritis · 2026 · Related
  17. Ripk3 induces mitochondrial apoptosis via inhibition of FUNDC1 mitophagy in cardiac IR injury · Hao Zhou · 2017 · 313 citations · Cited by this paper
  18. Orforglipron alleviates aortic aneurysm and dissection via inhibiting WNT5A noncanonical signaling · 2026 · Related
  19. Oxidative stress: Roles in skeletal muscle atrophy · Han Zhang · 2023 · 298 citations · Cited by this paper
  20. Glycoprotein nonmetastatic B as a pharmacological target in cancer: structural mechanisms, druggability, and therapeutic translation · 2026 · Related
  21. The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis · Michio Onizawa · 2015 · 288 citations · Cited by this paper
  22. RIPK3 Orchestrates Fatty Acid Metabolism in Tumor-Associated Macrophages and Hepatocarcinogenesis · Lei Wu · 2020 · 286 citations · Cited by this paper
  23. RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells · Ulrike Höckendorf · 2016 · 207 citations · Cited by this paper
  24. O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3 · Xinghui Li · 2019 · 207 citations · Cited by this paper
  25. RIPK3 promotes sepsis-induced acute kidney injury via mitochondrial dysfunction · Angara Sureshbabu · 2018 · 203 citations · Cited by this paper
  26. CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3 · Jinho Seo · 2016 · 188 citations · Cited by this paper
  27. Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs · Sofie Martens · 2020 · 180 citations · Cited by this paper
  28. Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis · SuHyeon Oh · 2023 · 180 citations · Cited by this paper
  29. AMPK/SIRT1/PGC‐1α Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy · Junyang Chen · 2025 · 171 citations · Cited by this paper
  30. A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing · Kenta Moriwaki · 2015 · 163 citations · Cited by this paper
  31. RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD · Hui Chen · 2018 · 148 citations · Cited by this paper
  32. Sublethal necroptosis signaling promotes inflammation and liver cancer · Mihael Vucur · 2023 · 146 citations · Cited by this paper
  33. PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons · Weitao Yan · 2022 · 139 citations · Cited by this paper
  34. RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis · Hui Chen · 2020 · 134 citations · Cited by this paper
  35. A RIPK3-PGE2 Circuit Mediates Myeloid-Derived Suppressor Cell–Potentiated Colorectal Carcinogenesis · Guifang Yan · 2018 · 126 citations · Cited by this paper
  36. Chronic kidney disease-induced muscle atrophy: Molecular mechanisms and promising therapies · Kexin Wang · 2022 · 126 citations · Cited by this paper
  37. Necroptosis blockade prevents lung injury in severe influenza · Avishekh Gautam · 2024 · 123 citations · Cited by this paper
  38. SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses · Shufen Li · 2023 · 113 citations · Cited by this paper
  39. Mosaic composition of RIP1–RIP3 signalling hub and its role in regulating cell death · Xin Chen · 2022 · 112 citations · Cited by this paper

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