Research map: Glypican-3-targeted therapy in hepatocellular carcinoma: biological insights and therapeutic strategies

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Papers in this map

  1. Understanding the tumor immune microenvironment (TIME) for effective therapy · Mikhail Binnewies · 2018 · 6348 citations · Cited by this paper
  2. Glypican-3-targeted bioconjugates for hepatocellular carcinoma: design, engineering, and translational applications · Yi Liu · 2026 · Cites this paper
  3. The role of STAT3 in regulating ferroptosis in cancer: molecular mechanisms and targeted therapeutic perspectives · 2026 · Related
  4. Strategies and challenges for the next generation of antibody–drug conjugates · Alain Beck · 2017 · 2288 citations · Cited by this paper
  5. b-AP15 enhances TRAIL-induced cell death in HNSCC via the induction of ROS/JNK/DR5 signalling · 2026 · Related
  6. Human chimeric antigen receptor macrophages for cancer immunotherapy · Michael Klichinsky · 2020 · 1499 citations · Cited by this paper
  7. COL3A1 promotes gastric cancer progression by activating PI3K/AKT signaling · 2026 · Related
  8. Bispecific antibodies: a mechanistic review of the pipeline · Aran F. Labrijn · 2019 · 1332 citations · Cited by this paper
  9. Inhibiting CXCL12/CXCR4 axis enhances T cell activity in gastric cancer · 2026 · Related
  10. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma · Mariana Capurro · 2003 · 923 citations · Cited by this paper
  11. Memory programming and new manufacturing paradigms in CAR-T cell therapy · 2026 · Related
  12. Toxicity and management in CAR T-cell therapy · Challice Lee Bonifant · 2016 · 908 citations · Cited by this paper
  13. Dioscin suppresses tumorigenesis and overcomes radioresistance by promoting ubiquitination-mediated degradation of Mcl-1 · 2026 · Related
  14. Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion · Nicole E. Scharping · 2021 · 902 citations · Cited by this paper
  15. SPARC family proteins: matricellular modulators of cancer progression and therapeutic resistance · 2026 · Related
  16. Natural killer cells in cancer biology and therapy · Song‐Yang Wu · 2020 · 897 citations · Cited by this paper
  17. HOXC11 promotes head and neck squamous cell carcinomas (HNSCC) progression by regulating SPHK1 through the Wnt signaling pathway · 2026 · Related
  18. Antibody–drug conjugates come of age in oncology · Charles Dumontet · 2023 · 849 citations · Cited by this paper
  19. The Tumor-suppressive role of CNTNAP2 in glioma: Dual regulation of the NDN-ERK axis and M2 macrophage polarization · 2026 · Related
  20. T cell receptor (TCR) signaling in health and disease · Kinjal Shah · 2021 · 617 citations · Cited by this paper
  21. A phase I study of multi-HLA-binding peptides derived from heat shock protein 70/glypican-3 and a novel combination adjuvant of hLAG-3Ig and Poly-ICLC for patients with metastatic gastrointestinal cancers: YNP01 trial · 2020 · Related
  22. Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy · Gavin M. Bendle · 2010 · 450 citations · Cited by this paper
  23. Glypican‐3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment · Fubo Zhou · 2017 · 407 citations · Cited by this paper
  24. Cytokine Release Syndrome with Chimeric Antigen Receptor T Cell Therapy · Noelle V. Frey · 2018 · 404 citations · Cited by this paper
  25. Chimeric Antigen Receptor-Glypican-3 T-Cell Therapy for Advanced Hepatocellular Carcinoma: Results of Phase I Trials · Donghua Shi · 2020 · 386 citations · Cited by this paper
  26. Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma · Huiping Gao · 2014 · 313 citations · Cited by this paper
  27. Phase I Trial of a Glypican-3–Derived Peptide Vaccine for Advanced Hepatocellular Carcinoma: Immunologic Evidence and Potential for Improving Overall Survival · Yu Sawada · 2012 · 304 citations · Cited by this paper
  28. Chimeric antigen receptor macrophage therapy for breast tumours mediated by targeting the tumour extracellular matrix · Wenlong Zhang · 2019 · 295 citations · Cited by this paper
  29. Cancer Therapy With TCR-Engineered T Cells: Current Strategies, Challenges, and Prospects · Paul W. Shafer · 2022 · 271 citations · Cited by this paper
  30. Glypican-3–Specific CAR T Cells Coexpressing IL15 and IL21 Have Superior Expansion and Antitumor Activity against Hepatocellular Carcinoma · Sai Arun Batra · 2020 · 265 citations · Cited by this paper
  31. Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers · David Steffin · 2024 · 256 citations · Cited by this paper
  32. Engineered CAR-Macrophages as Adoptive Immunotherapies for Solid Tumors · Christopher Sloas · 2021 · 246 citations · Cited by this paper
  33. CAR-macrophage: A new immunotherapy candidate against solid tumors · Yizhao Chen · 2021 · 243 citations · Cited by this paper
  34. DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy · Beatriz Sánchez-Correa · 2019 · 218 citations · Cited by this paper
  35. An anti–glypican 3/CD3 bispecific T cell–redirecting antibody for treatment of solid tumors · Takahiro Ishiguro · 2017 · 213 citations · Cited by this paper
  36. First-in-Man Phase I Study of GC33, a Novel Recombinant Humanized Antibody Against Glypican-3, in Patients with Advanced Hepatocellular Carcinoma · Andrew Xiuxuan Zhu · 2013 · 197 citations · Cited by this paper
  37. Tumor Heterogeneity: A Great Barrier in the Age of Cancer Immunotherapy · Nader El-Sayes · 2021 · 197 citations · Cited by this paper
  38. Off-the-shelf Vδ1 gamma delta T cells engineered with glypican-3 (GPC-3)-specific chimeric antigen receptor (CAR) and soluble IL-15 display robust antitumor efficacy against hepatocellular carcinoma · Amani Makkouk · 2021 · 197 citations · Cited by this paper
  39. Development of GPC3-Specific Chimeric Antigen Receptor-Engineered Natural Killer Cells for the Treatment of Hepatocellular Carcinoma · Min Yu · 2017 · 189 citations · Cited by this paper

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