Glypican-3-targeted therapy in hepatocellular carcinoma: biological insights and therapeutic strategies

Cancer Gene Therapy · Published 2026-07-23 · DOI 10.1038/s41417-026-01058-z

Authors (12)

Na Li, Shurong Li, Peng Cao, Mengfan Tang, Junfeng Zhang, Wei Zhang, Jinfeng Liu, Chunping Ye, Dan Wu, Xixi Li, Li Dai, Xianglin Zuo

Abstract

PubPorta does not have an abstract for this article yet.

Read the article at the publisher →

Publication details

Year

2026

Citation

Li, N., Li, S., Cao, P., et al. (2026). Glypican-3-targeted therapy in hepatocellular carcinoma: biological insights and therapeutic strategies. Cancer Gene Therapy. https://doi.org/10.1038/s41417-026-01058-z

Related articles

• A phase I study of multi-HLA-binding peptides derived from heat shock protein 70/glypican-3 and a novel combination adjuvant of hLAG-3Ig and Poly-ICLC for patients with metastatic gastrointestinal cancers: YNP01 trial · Cancer Immunology, Immunotherapy · 2020 · Cites or is cited by this article
• The role of STAT3 in regulating ferroptosis in cancer: molecular mechanisms and targeted therapeutic perspectives · Cancer Gene Therapy · 2026 · Same journal
• b-AP15 enhances TRAIL-induced cell death in HNSCC via the induction of ROS/JNK/DR5 signalling · Cancer Gene Therapy · 2026 · Same journal
• COL3A1 promotes gastric cancer progression by activating PI3K/AKT signaling · Cancer Gene Therapy · 2026 · Same journal
• Inhibiting CXCL12/CXCR4 axis enhances T cell activity in gastric cancer · Cancer Gene Therapy · 2026 · Same journal
• Memory programming and new manufacturing paradigms in CAR-T cell therapy · Cancer Gene Therapy · 2026 · Same journal
• Dioscin suppresses tumorigenesis and overcomes radioresistance by promoting ubiquitination-mediated degradation of Mcl-1 · Cancer Gene Therapy · 2026 · Same journal
• SPARC family proteins: matricellular modulators of cancer progression and therapeutic resistance · Cancer Gene Therapy · 2026 · Same journal
• HOXC11 promotes head and neck squamous cell carcinomas (HNSCC) progression by regulating SPHK1 through the Wnt signaling pathway · Cancer Gene Therapy · 2026 · Same journal
• The Tumor-suppressive role of CNTNAP2 in glioma: Dual regulation of the NDN-ERK axis and M2 macrophage polarization · Cancer Gene Therapy · 2026 · Same journal