Research map: Parkinson’s disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytes

Back to the article

Papers in this map

  1. Ferroptosis: process and function · Yang Xie · 2016 · 3854 citations · Cited by this paper
  2. An LRRK2 variant blocks NCOA4 trafficking upon iron overload, leading to ferroptotic death · Andrés Goldman · 2026 · 3 citations · Cites this paper
  3. Mitochondria transfer in neurological disorders: the key role of neuroglia · 2026 · Related
  4. Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells · Yingsha Zhang · 2013 · 1826 citations · Cited by this paper
  5. LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death · Andrés Goldman · 2025 · Cites this paper
  6. AQP4-dependent enhancement of glymphatic function attenuates tau pathology and neurodegeneration in PS19 mice · 2026 · Related
  7. Religious Orders Study and Rush Memory and Aging Project · David Alan Bennett · 2018 · 1416 citations · Cited by this paper
  8. Dual-Pathway Astrocyte Failure in Parkinson’s Disease: Therapeutic Targeting of Nrf2/TFEB Suppression and cGAS-STING/Ferroptosis Activation · Ahmed M Abdelaziz · 2026 · Cites this paper
  9. Plasma platelet-derived growth factor receptor-β decrease correlates with blood-brain barrier damage in Alzheimer’s disease · 2026 · Related
  10. Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases · Martin Steger · 2016 · 1103 citations · Cited by this paper
  11. Lipid alterations in hereditary peripheral neuropathies: common mechanisms in disease heterogeneity? · 2026 · Related
  12. GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis · Giovanni C. Forcina · 2019 · 1099 citations · Cited by this paper
  13. Plasma proteomic signatures of preclinical Alzheimer’s disease in clinically unimpaired older adults · 2026 · Related
  14. The role of iron regulatory proteins in mammalian iron homeostasis and disease · Tracey Ann Rouault · 2006 · 1079 citations · Cited by this paper
  15. Phospho-ubiquitin: rewriting the ubiquitin code · 2026 · Related
  16. INCREASED NIGRAL IRON CONTENT IN POSTMORTEM PARKINSONIAN BRAIN · David Trevor Dexter · 1987 · 971 citations · Cited by this paper
  17. Systemic complement factors in aging, Alzheimer’s disease and other dementias: a longitudinal study over 10 years · 2026 · Related
  18. Kinase activity is required for the toxic effects of mutant LRRK2/dardarin · Elisa Greggio · 2006 · 759 citations · Cited by this paper
  19. Atypical chemokine receptor 3 regulates synaptic removal in disease astrocytes · 2026 · Related
  20. Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain · Emin Sofic · 1988 · 756 citations · Cited by this paper
  21. Transplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice · 2026 · Related
  22. Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC · Bruce Do Van · 2016 · 709 citations · Cited by this paper
  23. Tau oligomers modulate synapse fate by eliciting progressive bipartite synapse dysregulation and synapse loss · 2026 · Related
  24. The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis · Heather Booth · 2017 · 682 citations · Cited by this paper
  25. The position of lysosomes within the cell determines their luminal pH · Danielle Johnson · 2016 · 629 citations · Cited by this paper
  26. Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity · Andrew B. West · 2007 · 614 citations · Cited by this paper
  27. Iron and Aluminum Increase in the Substantia Nigra of Patients with Parkinson's Disease: An X‐Ray Microanalysis · Étienne C. Hirsch · 1991 · 539 citations · Cited by this paper
  28. Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis · Marietta Zille · 2017 · 531 citations · Cited by this paper
  29. Characteristics and Biomarkers of Ferroptosis · Xin Chen · 2021 · 526 citations · Cited by this paper
  30. Localization of LRRK2 to membranous and vesicular structures in mammalian brain · Saskia Biskup · 2006 · 521 citations · Cited by this paper
  31. Iron Metabolism and the IRE/IRP Regulatory System: An Update · Kostas Pantopoulos · 2004 · 513 citations · Cited by this paper
  32. Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis · Ruilin Tian · 2021 · 432 citations · Cited by this paper
  33. Ferroptosis Mechanisms Involved in Neurodegenerative Diseases · Cadiele Oliana Reichert · 2020 · 431 citations · Cited by this paper
  34. The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells · Mami Sato · 2018 · 416 citations · Cited by this paper
  35. Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease · Julio Salazar · 2008 · 415 citations · Cited by this paper
  36. Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease · Angelique di Domenico · 2019 · 388 citations · Cited by this paper
  37. LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis · Tomoya Eguchi · 2018 · 357 citations · Cited by this paper
  38. Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation · Plamena R. Angelova · 2020 · 317 citations · Cited by this paper
  39. The physiological functions of iron regulatory proteins in iron homeostasis - an update · De‐Liang Zhang · 2014 · 308 citations · Cited by this paper

Source: OpenAlex (CC0)