Research map: Efflux-mediated carbapenem resistance: unveiling genetic drivers, clinical implications, and strategies for global antimicrobial stewardship

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  1. Multidrug efflux pumps: structure, function and regulation · Dijun Du · 2018 · 1088 citations · Cited by this paper
  2. Detection of nontuberculous mycobacteria in milk and nasal swab of cattle tested positive by tuberculin skin test, Interferon-γ release assay and MycoPac dual lateral flow assay · 2026 · Related
  3. Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance · Lucía Fernández · 2012 · 898 citations · Cited by this paper
  4. Integrating machine learning and WGCNA to identify core candidate genes and decipher immune-related molecular networks in TcdA/TcdB-associated CDI · 2026 · Related
  5. Efflux pumps as antimicrobial resistance mechanisms · Keith G. Poole · 2007 · 564 citations · Cited by this paper
  6. Duganella paludis sp. nov. and Pedobacter jaeyakensis sp. nov., isolated from the wetland fresh water · 2026 · Related
  7. A Dose-Response Study of Antibiotic Resistance in Pseudomonas aeruginosa Biofilms · Alexei Brooun · 2000 · 477 citations · Cited by this paper
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  9. Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein · Emiko Y. Rosenberg · 2003 · 470 citations · Cited by this paper
  10. Stenotrophomonas maltophilia in a Rhipicephalus linnaei tick cell culture: detection, antibiotic resistance and multi-locus sequence typing · 2026 · Related
  11. Efflux pump inhibitors for bacterial pathogens · Atin Sharma · 2019 · 461 citations · Cited by this paper
  12. Deterministic selection and compositional turnover in Parkinson’s disease-associated gut dysbiosis · 2026 · Related
  13. Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors · Amit Gaurav · 2023 · 350 citations · Cited by this paper
  14. Marine microorganisms as probiotics in the aquaculture of sea cucumber (Apostichopus japonicus) · 2026 · Related
  15. Multidrug Efflux Pumps: Expression Patterns and Contribution to Antibiotic Resistance in Pseudomonas aeruginosa Biofilms · Teresa R. de Kievit · 2001 · 299 citations · Cited by this paper
  16. Coordinated attenuation of oxidative stress metabolism and alterations of root exudates in maize (Zea mays L.) induced by Streptomyces rhizobacteria · 2026 · Related
  17. Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview · Lulu Huang · 2022 · 284 citations · Cited by this paper
  18. SEM and FESEM-based structural elucidation and molecular characterization of isolated Astraeus asiaticus spp. from sal forest · 2026 · Related
  19. Function and Inhibitory Mechanisms of Multidrug Efflux Pumps · Kunihiko Nishino · 2021 · 235 citations · Cited by this paper
  20. Heterologous expression reveals a cryptic morphogenetic lanthipeptide durhapeptin from Streptomyces durhamensis · 2026 · Related
  21. RND multidrug efflux pumps: what are they good for? · Carolina Alvarez‐Ortega · 2013 · 230 citations · Cited by this paper
  22. Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: a review · Wubetu Yihunie Belay · 2024 · 229 citations · Cited by this paper
  23. Tripartite assembly of RND multidrug efflux pumps · Laetitia Daury · 2016 · 219 citations · Cited by this paper
  24. Fluorometric determination of ethidium bromide efflux kinetics in Escherichia coli · Laura Paixão · 2009 · 216 citations · Cited by this paper
  25. Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Pathogenic Bacteria · Ronit Vogt Sionov · 2022 · 214 citations · Cited by this paper
  26. Physiological Functions of Bacterial “Multidrug” Efflux Pumps · Peter J. F. Henderson · 2021 · 209 citations · Cited by this paper
  27. Efflux pump inhibitors of clinically relevant multidrug resistant bacteria · Andraž Lamut · 2019 · 204 citations · Cited by this paper
  28. Molecular Basis of Azithromycin-Resistant Pseudomonas aeruginosa Biofilms · Richard J. Gillis · 2005 · 184 citations · Cited by this paper
  29. Bacterial Multidrug Efflux Transporters · Jared A. Delmar · 2014 · 183 citations · Cited by this paper
  30. MexAB‐OprM hyperexpression in NalC‐type multidrug‐resistant Pseudomonas aeruginosa: identification and characterization of the nalC gene encoding a repressor of PA3720‐PA3719 · Lily Cao · 2004 · 159 citations · Cited by this paper
  31. RND Efflux Pumps in Gram-Negative Bacteria; Regulation, Structure and Role in Antibiotic Resistance · Abigail L. Colclough · 2020 · 148 citations · Cited by this paper
  32. Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism · Kenta Tsutsumi · 2019 · 136 citations · Cited by this paper
  33. The future of pharmaceuticals: Artificial intelligence in drug discovery and development · Chen Fu · 2025 · 135 citations · Cited by this paper
  34. CpxR Activates MexAB-OprM Efflux Pump Expression and Enhances Antibiotic Resistance in Both Laboratory and Clinical nalB-Type Isolates of Pseudomonas aeruginosa · Zhe‐Xian Tian · 2016 · 132 citations · Cited by this paper
  35. Multidrug resistant Acinetobacter baumannii--the role of AdeABC (RND family) efflux pump in resistance to antibiotics. · Piotr Wieczorek · 2008 · 120 citations · Cited by this paper
  36. AcrAB-TolC, a major efflux pump in Gram negative bacteria: toward understanding its operation mechanism · Soojin Jang · 2023 · 117 citations · Cited by this paper
  37. Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria · Nina Compagne · 2023 · 109 citations · Cited by this paper
  38. Efflux Pump-Driven Antibiotic and Biocide Cross-Resistance in Pseudomonas aeruginosa Isolated from Different Ecological Niches: A Case Study in the Development of Multidrug Resistance in Environmental Hotspots · Anteneh Amsalu · 2020 · 108 citations · Cited by this paper
  39. Evaluation of Multidrug Efflux Pump Inhibitors by a New Method Using Microfluidic Channels · Yoshimi Matsumoto · 2011 · 98 citations · Cited by this paper

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