Research map: Immunopathogenesis of itch: an integrative framework for chronic pruritus

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  1. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. · Timothy R. Mosmann · 1986 · 7550 citations · Cited by this paper
  2. High-salt diet aggravates skin inflammation of psoriasis-like mouse model with CCL20‒CCR6 axis further activation · 2026 · Related
  3. Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages · Laurie E. Harrington · 2005 · 4763 citations · Cited by this paper
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  7. Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing · Dmitry Usoskin · 2014 · 2304 citations · Cited by this paper
  8. Development of a noninvasive device and method for measuring immune parameters in skin disease · 2026 · Related
  9. Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis · Eric Lawrence Simpson · 2016 · 2103 citations · Cited by this paper
  10. Plasma proteomic profiles of patients with atopic dermatitis with moderate-to-severe pruritus treated with a single dose of nemolizumab · 2026 · Related
  11. The Sensory Neurons of Touch · Victoria E. Abraira · 2013 · 1700 citations · Cited by this paper
  12. Contribution of HMGB1 to keratinocyte inflammation in recessive dystrophic epidermolysis bullosa · 2026 · Related
  13. Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor · Jean‐Michel Arrang · 1983 · 1583 citations · Cited by this paper
  14. Human keratinocytes exhibit limited potential for SARS-CoV-2 infection despite ACE2 and mature cathepsin L expression · 2025 · Related
  15. The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria · Torsten Zuberbier · 2021 · 1256 citations · Cited by this paper
  16. A bioelectric dressing improves postderoofing outcomes in hidradenitis suppurativa by microbiome modulation: A split-body, randomized clinical trial · 2026 · Related
  17. Histamine in the Nervous System · Helmut L. Haas · 2008 · 1236 citations · Cited by this paper
  18. Neuroimmune interactions between itch neurons and skin microbes · 2025 · Related
  19. Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch · Landon K. Oetjen · 2017 · 1105 citations · Cited by this paper
  20. Clinical Trial Comparison of Dupilumab and Nemolizumab for Prurigo Nodularis FDA-Approved Biologic Therapy Selection in Prurigo Nodularis · 2026 · Related
  21. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice · Stacey R. Dillon · 2004 · 1025 citations · Cited by this paper
  22. The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch · Sarah R. Wilson · 2013 · 1000 citations · Cited by this paper
  23. The neurobiology of itch · Akihiko Ikoma · 2006 · 960 citations · Cited by this paper
  24. JAKs and STATs in Immunity, Immunodeficiency, and Cancer · John J. O’Shea · 2013 · 941 citations · Cited by this paper
  25. Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases · Keith D. Lindor · 2018 · 921 citations · Cited by this paper
  26. Specific C-Receptors for Itch in Human Skin · Martin Schmelz · 1997 · 911 citations · Cited by this paper
  27. The physiological action of β‐iminazolylethylamine · Henry Hallett Dale · 1910 · 887 citations · Cited by this paper
  28. Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus · Qin Liu · 2009 · 833 citations · Cited by this paper
  29. A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1 · Ferda Cevikbas · 2013 · 812 citations · Cited by this paper
  30. A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord · Yan-Gang Sun · 2007 · 803 citations · Cited by this paper
  31. Clinical Classification of Itch: a Position Paper of the International Forum for the Study of Itch · Sonja Ständer · 2007 · 768 citations · Cited by this paper
  32. The JAK-STAT pathway at 30: Much learned, much more to do · Rachael Laura Philips · 2022 · 746 citations · Cited by this paper
  33. Efficacy and safety of risankizumab in moderate-to-severe plaque psoriasis (UltIMMa-1 and UltIMMa-2): results from two double-blind, randomised, placebo-controlled and ustekinumab-controlled phase 3 trials · Kenneth B. Gordon · 2018 · 683 citations · Cited by this paper
  34. Mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma (MAVORIC): an international, open-label, randomised, controlled phase 3 trial · Youn H. Kim · 2018 · 673 citations · Cited by this paper
  35. Interaction of IL-2Rβ and γ c Chains with Jak1 and Jak3: Implications for XSCID and XCID · Sarah May Russell · 1994 · 660 citations · Cited by this paper
  36. Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin · Martin S. Steinhoff · 2003 · 653 citations · Cited by this paper
  37. A subpopulation of nociceptors specifically linked to itch · Liang Han · 2012 · 636 citations · Cited by this paper
  38. TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch · Sarah R. Wilson · 2011 · 613 citations · Cited by this paper
  39. Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors · Marek Jutel · 2001 · 594 citations · Cited by this paper

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