JID Innovations · Published 2026-01-20 · DOI 10.1016/j.xjidi.2026.100451
Epidermal keratinocytes are important for maintaining the skin barrier by interacting with immune cells and environmental stimuli. In this study, we reveal that a high-salt diet aggravated imiquimod-induced skin inflammation in a psoriasis-like mouse model, characterized by activation of the CCL20–CCR6 axis and increased infiltration of CCR6+ γδT cells in skin lesions. In the presence of additional sodium, the mRNA expression of Ccl20 was upregulated in keratinocytes, mediated by JNK/p38–SGK1 pathway. Consistent with our experimental findings, a positive correlation between SGK1 and CCL20 gene expression was also observed in the skin of patients with psoriasis. Taken together, these data demonstrated that a high-salt diet aggravated skin inflammation in a psoriasis-like mouse model through further activation of the CCL20‒CCR6 axis.
Abstract from DOAJ. Public domain (CC0 1.0).
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