Research map: The Gut–brain–adipose Axis in Ultra-processed Food and Obesity: A Mechanistic Synthesis and Its Implications for Food Classification

Papers in this map

1. Obesity is associated with macrophage accumulation in adipose tissue · Stuart Phillip Weisberg · 2003 · 8601 citations · Cited by this paper
2. When Ultra-Processed Foods are Eaten: The Missing Dimension in Exposure Measurement for Obesity Research · Jimmy Chun Yu Louie · 2026 · Cites this paper
3. Cross-Sector Policies for Achieving Equitable Obesity Prevention and Food Security: A Review of Real-World Actions · 2026 · Related
4. Metabolic Endotoxemia Initiates Obesity and Insulin Resistance · Patrice D. Cani · 2007 · 6668 citations · Cited by this paper
5. Emotional Eating and Obesity: An Update and New Insights · 2025 · Related
6. Adipokines in inflammation and metabolic disease · Noriyuki Bob Ouchi · 2011 · 4606 citations · Cited by this paper
7. Intersection between Eating Disorders and Obesity in Youth: Implications for Treatment · 2025 · Related
8. Ultra-processed foods: what they are and how to identify them · Carlos Augusto Monteiro · 2019 · 2955 citations · Cited by this paper
9. The Role of Fathers in the Intergenerational Transmission of Obesity · 2026 · Related
10. Inflammation, metaflammation and immunometabolic disorders · Gökhan S. Hotamışlıgil · 2017 · 2551 citations · Cited by this paper
11. Adult Growth Hormone Deficiency and Metabolic Dysfunction-Associated Steatotic Liver Disease · 2026 · Related
12. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans · Saverio Cinti · 2005 · 2530 citations · Cited by this paper
13. Obesogens in Prostate Cancer: An Endocrine and Metabolic Threat · 2026 · Related
14. The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids · Andrew J. Brown · 2003 · 2415 citations · Cited by this paper
15. The industrial formulation fallacy: a critical appraisal of the Nova classification system · 2026 · Related
16. Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis · Nagendra Kumar Singh · 2014 · 2375 citations · Cited by this paper
17. Trans Fatty Acids and Chronic Metabolic Diseases: Molecular Mechanisms and Public Health Strategies for Risk Mitigation · 2025 · Related
18. Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers · Luying Peng · 2009 · 2145 citations · Cited by this paper
19. Ultra-processed food consumption affects structural integrity of feeding-related brain regions independent of and via adiposity · 2025 · Related
20. Artificial sweeteners induce glucose intolerance by altering the gut microbiota · Jotham Suez · 2014 · 2083 citations · Cited by this paper
21. Is the experimental evidence on ultra-processed food and obesity reliable? · 2026 · Related
22. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome · Benoît Chassaing · 2015 · 2058 citations · Cited by this paper
23. Bisphenol A and human health: A review of the literature · Johanna R. Rochester · 2013 · 2025 citations · Cited by this paper
24. Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake · Kevin D. Hall · 2019 · 1960 citations · Cited by this paper
25. Obesity is associated with hypothalamic injury in rodents and humans · Joshua P. Thaler · 2011 · 1886 citations · Cited by this paper
26. Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats · Paul Micah Johnson · 2010 · 1510 citations · Cited by this paper
27. Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity · Xiaoqing Zhang · 2008 · 1353 citations · Cited by this paper
28. Leptin and Obesity: Role and Clinical Implication · Milan M. Obradovic · 2021 · 1123 citations · Cited by this paper
29. Increasing consumption of ultra-processed foods and likely impact on human health: evidence from Brazil · Carlos Augusto Monteiro · 2010 · 1071 citations · Cited by this paper
30. Consumption of ultra-processed foods and health status: a systematic review and meta-analysis · Giuditta Pagliai · 2020 · 1055 citations · Cited by this paper
31. Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk · Jennifer H. Stern · 2016 · 1054 citations · Cited by this paper
32. Ultra-processed food intake and risk of cardiovascular disease: prospective cohort study (NutriNet-Santé) · Bernard Srour · 2019 · 944 citations · Cited by this paper
33. Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations · Mohan Manikkam · 2013 · 907 citations · Cited by this paper
34. Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses · Melissa M. Lane · 2024 · 854 citations · Cited by this paper
35. Beverage purchases from stores in Mexico under the excise tax on sugar sweetened beverages: observational study · M. Arantxa Colchero · 2016 · 835 citations · Cited by this paper
36. Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers · Nielson T. Baxter · 2019 · 796 citations · Cited by this paper
37. Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia · Ana Paula Boroni Moreira · 2012 · 663 citations · Cited by this paper
38. Which Foods May Be Addictive? The Roles of Processing, Fat Content, and Glycemic Load · Erica M. LaFata · 2015 · 660 citations · Cited by this paper
39. Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation · Benoît Chassaing · 2017 · 593 citations · Cited by this paper

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