Research map: Locking the TMEM16A chloride channel into its conductive state

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Papers in this map

  1. TMEM16A confers receptor-activated calcium-dependent chloride conductance · Young Duk Yang · 2008 · 1305 citations · Cited by this paper
  2. Cholesterol pools cooperate to modulate HCN channels · 2026 · Related
  3. TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity · Antonella Caputo · 2008 · 1288 citations · Cited by this paper
  4. Dysferlin’s C2A domain supports normal Ca2+ signaling and membrane repair in dysferlin-null myofibers · 2026 · Related
  5. Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit · Björn C. Schroeder · 2008 · 1168 citations · Cited by this paper
  6. On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC · 2025 · Related
  7. Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing · Loretta Ferrera · 2009 · 211 citations · Cited by this paper
  8. Combining elastic network models and linear response theory as tool to understand the global dynamics in allosteric regulation of HCN channels · 2026 · Related
  9. The Groovy TMEM16 Family: Molecular Mechanisms of Lipid Scrambling and Ion Conduction · Valeria Kalienkova · 2021 · 105 citations · Cited by this paper
  10. Coincidence detection supported by electrical synapses is shaped by the D-type K+ current · 2026 · Related
  11. Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A · Son C. Le · 2019 · 103 citations · Cited by this paper
  12. Evolution, hibernation, and inactivation of voltage-gated Na channels · 2026 · Related
  13. A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca 2+ -activated Cl − channel ANO1 (TMEM16A) · Kuai Yu · 2019 · 79 citations · Cited by this paper
  14. Model of ocular surface ion and water transport predicts efficacy of dry eye therapeutics · 2026 · Related
  15. TMEM16 scramblases thin the membrane to enable lipid scrambling · Maria E. Falzone · 2022 · 73 citations · Cited by this paper
  16. Inhibition of CaV1.4 channels by CaV3 channel antagonists ML218 and Z944 · 2025 · Related
  17. Structural basis for the activation of the lipid scramblase TMEM16F · Melanie Arndt · 2022 · 61 citations · Cited by this paper
  18. A critical residue mediates proper assembly and gating of GIRK2 channels · 2025 · Related
  19. Gating the pore of the calcium-activated chloride channel TMEM16A · Andy K.M. Lam · 2021 · 60 citations · Cited by this paper
  20. Dissecting π‐helices: sequence, structure and function · Prasun Kumar · 2015 · 45 citations · Cited by this paper
  21. Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16 · George Khelashvili · 2019 · 37 citations · Cited by this paper
  22. Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC · Andy K.M. Lam · 2022 · 29 citations · Cited by this paper
  23. Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling · Shengjie Feng · 2019 · 18 citations · Cited by this paper
  24. In or out of the groove? Mechanisms of lipid scrambling by TMEM16 proteins · Zhang Feng · 2024 · 12 citations · Cited by this paper
  25. Calcium-activated chloride channel TMEM16A opens via pi-helical transition in transmembrane segment 4 · Andrei Yu. Kostritskii · 2025 · 6 citations · Cited by this paper
  26. Calcium dependent activation of the TMEM16F scramblase and ion channel · Zhang Feng · 2026 · 2 citations · Cited by this paper
  27. Conformational changes upon pore blocker removal reveal conductive states of TMEM16A · Christina Alexandra Stephens · 2026 · 1 citation · Cited by this paper

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