Research map: PARP7 enhances doxorubicin-induced cardiomyocyte ferroptosis and cardiotoxicity by ADP-ribosylation-dependent suppression of GPX4 activity

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  1. Regulation of Ferroptotic Cancer Cell Death by GPX4 · Wan Seok Yang · 2014 · 7840 citations · Cited by this paper
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  23. Pharmacological activation of GPX4 ameliorates doxorubicin-induced cardiomyopathy · Chuying Huang · 2024 · 74 citations · Cited by this paper
  24. Gasdermin D mediates doxorubicin-induced cardiomyocyte pyroptosis and cardiotoxicity via directly binding to doxorubicin and changes in mitochondrial damage · Bozhi Ye · 2022 · 72 citations · Cited by this paper
  25. Molecular Mechanisms and Therapeutic Targeting of Ferroptosis in Doxorubicin-Induced Cardiotoxicity · Lin Wu · 2024 · 64 citations · Cited by this paper
  26. Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction by stabilizing SERCA2a in cardiomyocytes · Jibo Han · 2023 · 37 citations · Cited by this paper
  27. Cardiac gene therapy: Recent advances and future directions · Daniel J. Mason · 2015 · 30 citations · Cited by this paper
  28. The recent advance and prospect of poly(ADP‐ribose) polymerase inhibitors for the treatment of cancer · Yi‐Ru Bai · 2024 · 23 citations · Cited by this paper
  29. PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease · Devon Jeltema · 2025 · 22 citations · Cited by this paper
  30. Targeting the TRIM14/USP14 axis enhances radiotherapy efficacy by inducing GPX4 degradation and disrupting ferroptotic defense in HCC · Xin Yue · 2025 · 22 citations · Cited by this paper
  31. Discovery of Highly Selective PARP7 Inhibitors with a Novel Scaffold for Cancer Immunotherapy · Hong‐Feng Gu · 2023 · 20 citations · Cited by this paper
  32. Cardiomyocyte-derived USP13 protects hearts from hypertrophy via deubiquitinating and stabilizing STAT1 in male mice · Jibo Han · 2025 · 16 citations · Cited by this paper
  33. PARP-2 mediates cardiomyocyte aging and damage induced by doxorubicin through SIRT1 Inhibition · Chaoming Huang · 2024 · 14 citations · Cited by this paper
  34. Deubiquitinase USP13 alleviates doxorubicin-induced cardiotoxicity through promoting the autophagy-mediated degradation of STING · Liming Lin · 2025 · 13 citations · Cited by this paper
  35. PARP7i Clinical Candidate RBN‐2397 Exerts Antiviral Activity by Modulating Interferon‐β Associated Innate Immune Response in Macrophages · Xiaoli Du · 2024 · 10 citations · Cited by this paper
  36. MYSM1 Mediates Cardiac Parthanatos and Hypertrophy by Deubiquitinating PARP1 · Xin Zhong · 2025 · 9 citations · Cited by this paper
  37. Poly (ADP-ribose) polymerase pathway inhibitor (Olaparib) upregulates SERCA2a expression and attenuates doxorubicin-induced cardiomyopathy in mice · Rania Elkatary · 2023 · 7 citations · Cited by this paper
  38. PARP7: an Emerging Therapeutic Target-Insights into Biological Functions and Advances in Small-Molecule Inhibitor Development · Feihuang Qiu · 2025 · 6 citations · Cited by this paper

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