Research map: Circadian rhythm disruption induces cardiac hypertrophy via promoting the mtDNA release-activated cGAS-STING pathway

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Papers in this map

  1. cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING · Andrea Ablasser · 2013 · 1706 citations · Cited by this paper
  2. Genetic polymorphisms of drug-metabolizing cytochromes P450 and flavin-containing monooxygenases in dogs and pigs inform the prediction of drug metabolism and toxicity in humans and other animal species · Yasuhiro Uno · 2026 · Related
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  9. The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy · Patrick Kwabena Oduro · 2021 · 340 citations · Cited by this paper
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  11. Dim Light at Night Disrupts Molecular Circadian Rhythms and Increases Body Weight · Laura K. Fonken · 2013 · 325 citations · Cited by this paper
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  13. Mitochondrial damage and activation of the cytosolic DNA sensor cGAS–STING pathway lead to cardiac pyroptosis and hypertrophy in diabetic cardiomyopathy mice · Meiling Yan · 2022 · 275 citations · Cited by this paper
  14. HDAC1-mediated PKM2 delactylation modification regulates CIRP-induced angiogenesis in rheumatoid arthritis · 2026 · Related
  15. Cyclic GMP–AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA · Kazuki Kato · 2017 · 263 citations · Cited by this paper
  16. Orforglipron alleviates aortic aneurysm and dissection via inhibiting WNT5A noncanonical signaling · 2026 · Related
  17. Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism · O. Hecmarie Meléndez‐Fernández · 2023 · 223 citations · Cited by this paper
  18. Glycoprotein nonmetastatic B as a pharmacological target in cancer: structural mechanisms, druggability, and therapeutic translation · 2026 · Related
  19. Mitochondrial Structure and Function in Human Heart Failure · Antentor Othrell Hinton Jr. · 2024 · 218 citations · Cited by this paper
  20. Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes · Xiu Mei Ma · 2022 · 205 citations · Cited by this paper
  21. Critical Role of the cGAS-STING Pathway in Doxorubicin-Induced Cardiotoxicity · Wei Luo · 2023 · 183 citations · Cited by this paper
  22. Poor sleep and shift work associate with increased blood pressure and inflammation in UK Biobank participants · Monica Kanki · 2023 · 120 citations · Cited by this paper
  23. Light at Night Alters Daily Patterns of Cortisol and Clock Proteins in Female Siberian Hamsters · Tracy A. Bedrosian · 2013 · 108 citations · Cited by this paper
  24. Heart rate variability and endothelial function after sleep deprivation and recovery sleep among male shift and non-shift workers · Sophie M. T. Wehrens · 2011 · 95 citations · Cited by this paper
  25. PINK1-mediated mitophagy attenuates pathological cardiac hypertrophy by suppressing the mtDNA release-activated cGAS-STING pathway · Haobin Zhou · 2024 · 87 citations · Cited by this paper
  26. iNOS aggravates pressure overload-induced cardiac dysfunction via activation of the cytosolic-mtDNA-mediated cGAS-STING pathway · Yongzheng Guo · 2023 · 82 citations · Cited by this paper
  27. Circadian Influences on Myocardial Ischemia-Reperfusion Injury and Heart Failure · Tobias de la Garza Eckle · 2024 · 55 citations · Cited by this paper
  28. Circadian Rhythms in Cardiovascular Metabolism · Hind Lal · 2024 · 55 citations · Cited by this paper
  29. Circadian Rhythms in Cardiovascular Function: Implications for Cardiac Diseases and Therapeutic Opportunities · Jiayue Lin · 2023 · 35 citations · Cited by this paper
  30. Puerarin-7-O-glucuronide, a water-soluble puerarin metabolite, prevents angiotensin II-induced cardiomyocyte hypertrophy by reducing oxidative stress · Ning Hou · 2017 · 28 citations · Cited by this paper
  31. Light Exposure at Night and Cardiovascular Disease Incidence · Daniel P. Windred · 2025 · 25 citations · Cited by this paper
  32. Circadian rhythm disorders elevate macrophages cytokines release and promote multiple tissues/organs dysfunction in mice · Zhen Sun · 2022 · 22 citations · Cited by this paper
  33. Hyperglycemia Induces Tear Reduction and Dry Eye in Diabetic Mice through the Norepinephrine–α1 Adrenergic Receptor–Mitochondrial Impairment Axis of Lacrimal Gland · Sai Mei Zhang · 2023 · 22 citations · Cited by this paper
  34. Neurogenic Hypertension Mediated Mitochondrial Abnormality Leads to Cardiomyopathy: Contribution of UPRmt and Norepinephrine-miR- 18a-5p-HIF-1α Axis · Shyam Sundar Nandi · 2021 · 21 citations · Cited by this paper
  35. Melatonin Alleviates Circadian Rhythm Disruption‐Induced Enhanced Luteinizing Hormone Pulse Frequency and Ovarian Dysfunction · Yujing Li · 2025 · 21 citations · Cited by this paper
  36. Oxidative stress in the RVLM mediates sympathetic hyperactivity induced by circadian disruption · Wei Duan · 2022 · 19 citations · Cited by this paper
  37. Chronic circadian rhythm disorder induces heart failure with preserved ejection fraction-like phenotype through the Clock-sGC-cGMP-PKG1 signaling pathway · Yiyang Che · 2024 · 18 citations · Cited by this paper
  38. Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice · Jiaqiang Zhang · 2024 · 18 citations · Cited by this paper
  39. Dual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in sleep-deprived mice · Jia Chen · 2024 · 17 citations · Cited by this paper

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