Research map: Transformation of NSCLC to SCLC: Insights into Molecular Alterations, Tumor Origin, and Therapeutic Advancements

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  1. Comprehensive genomic characterization of squamous cell lung cancers · Peter S. Hammerman · 2012 · 4082 citations · Cited by this paper
  2. Small cell transformation during acquired resistance to zongertinib in HER2-mutant non-small cell lung cancer: a case report · Danru Zheng · 2026 · Cites this paper
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  23. An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance · Lauren A. Byers · 2012 · 1139 citations · Cited by this paper
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  25. Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin · Matthew G. Oser · 2015 · 969 citations · Cited by this paper
  26. Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors · Yong Jia · 2016 · 907 citations · Cited by this paper
  27. The prevalence of EGFR mutation in patients with non-small cell lung cancer: a systematic review and meta-analysis · Yuelun Zhang · 2016 · 816 citations · Cited by this paper
  28. RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer · Matthew J. Niederst · 2015 · 655 citations · Cited by this paper
  29. Lineage plasticity in cancer: a shared pathway of therapeutic resistance · Àlvaro Quintanal-Villalonga · 2020 · 603 citations · Cited by this paper
  30. Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1 · Lauren A. Byers · 2012 · 581 citations · Cited by this paper
  31. Oncogenic activity of the c-Myc protein requires dimerization with Max · Bruno B. Amati · 1993 · 577 citations · Cited by this paper
  32. p73: Friend or foe in tumorigenesis · Gerry Melino · 2002 · 558 citations · Cited by this paper
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  34. SCLC Subtypes Defined by ASCL1, NEUROD1, POU2F3, and YAP1: A Comprehensive Immunohistochemical and Histopathologic Characterization · Marina K. Baine · 2020 · 532 citations · Cited by this paper
  35. EGFR -Mutant Adenocarcinomas That Transform to Small-Cell Lung Cancer and Other Neuroendocrine Carcinomas: Clinical Outcomes · Nicolas Marcoux · 2018 · 504 citations · Cited by this paper
  36. Concurrent RB1 and TP53 Alterations Define a Subset of EGFR-Mutant Lung Cancers at risk for Histologic Transformation and Inferior Clinical Outcomes · Michael David Offin · 2019 · 471 citations · Cited by this paper
  37. POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer · Yuhan Huang · 2018 · 447 citations · Cited by this paper
  38. The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance · Himisha Beltran · 2019 · 420 citations · Cited by this paper
  39. Genetic alterations defining NSCLC subtypes and their therapeutic implications · Larissa A. Pikor · 2013 · 385 citations · Cited by this paper

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