Research map: Luteolin alleviates inflammation by inhibiting the PI3K-Akt-FOXO3a pathway

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  1. Inflammation and aging: signaling pathways and intervention therapies · Xia Li · 2023 · 1415 citations · Cited by this paper
  2. Lipid-based nanocarrier-enabled combination therapy for breast cancer: overcoming drug resistance toward precision oncology · 2026 · Related
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  9. Luteolin: A promising multifunctional natural flavonoid for human diseases · Mingtao Zhu · 2024 · 174 citations · Cited by this paper
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  11. The flavonoid luteolin prevents lipopolysaccharide‐induced NF‐κB signalling and gene expression by blocking IκB kinase activity in intestinal epithelial cells and bone‐marrow derived dendritic cells · Joo Sung Kim · 2005 · 172 citations · Cited by this paper
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  17. Plantanone C attenuates LPS-stimulated inflammation by inhibiting NF-κB/iNOS/COX-2/MAPKs/Akt pathways in RAW 264.7 macrophages · Yiwei Fang · 2021 · 118 citations · Cited by this paper
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  19. Luteolin inhibits inflammation and M1 macrophage polarization in the treatment of Pseudomonas aeruginosa-induced acute pneumonia through suppressing EGFR/PI3K/AKT/NF-κB and EGFR/ERK/AP-1 signaling pathways · Mengdi Gu · 2025 · 61 citations · Cited by this paper
  20. Targeting early pulmonary fibrosis with bone marrow mesenchymal stem cells and their derived exosomes: a comparative study of inhalation versus injection delivery in bleomycin-induced rat lung injury · 2026 · Related
  21. Anti-inflammatory effect of phenylpropanoids from Dendropanax dentiger in TNF-α-induced MH7A cells via inhibition of NF-κB, Akt and JNK signaling pathways · Li Yang · 2021 · 54 citations · Cited by this paper
  22. Synergism between luteolin and sulforaphane in anti-inflammation · Kanyasiri Rakariyatham · 2018 · 52 citations · Cited by this paper
  23. Oxoisoaporphine Alkaloid Iridium(III) Derivative: An Immunogenic Cell Death Inducer That Engages the Autophagy-Dependent Regulator Cathepsin D · Lu Yuan · 2025 · 44 citations · Cited by this paper
  24. White Wine Induced Cardioprotection against Ischemia-Reperfusion Injury Is Mediated by Life Extending Akt/FOXO3a/NFκB Survival Pathway · Mahesh Thirunavukkarasu · 2008 · 43 citations · Cited by this paper
  25. Hostaflavone A from Hosta plantaginea (Lam.) Asch. blocked NF-κB/iNOS/COX-2/MAPKs/Akt signaling pathways in LPS-induced RAW 264.7 macrophages · Li Yang · 2021 · 43 citations · Cited by this paper
  26. Tempol Attenuates Renal Fibrosis in Mice with Unilateral Ureteral Obstruction: The Role of PI3K-Akt-FoxO3a Signaling · Hye Eun Yoon · 2014 · 42 citations · Cited by this paper
  27. Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies · Mahwish · 2025 · 38 citations · Cited by this paper
  28. Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K/AKT/FOXO3a pathway · Qi Xiao · 2017 · 35 citations · Cited by this paper
  29. Anti-inflammatory effects of flavonoids and phenylethanoid glycosides from Hosta plantaginea flowers in LPS-stimulated RAW 264.7 macrophages through inhibition of the NF-κB signaling pathway · Li Yang · 2022 · 35 citations · Cited by this paper
  30. Kaempferol 3-O-(2G-glucosylrutinoside)-7-O-glucoside isolated from the flowers of Hosta plantaginea exerts anti-inflammatory activity via suppression of NF-κB, MAPKs and Akt pathways in RAW 264.7 cells · Yiwei Fang · 2022 · 35 citations · Cited by this paper
  31. Chemoproteomics of Marine Natural Product Naamidine J Unveils CSE1L as a Therapeutic Target in Acute Lung Injury · Chenglong Gao · 2024 · 33 citations · Cited by this paper
  32. Dendropanax dentiger (Harms) Merr. root and its major constituents exert therapeutic effect on adjuvant-induced arthritis in rats · Li Yang · 2020 · 32 citations · Cited by this paper
  33. Lagopsis supina ameliorates myocardial ischemia injury by regulating angiogenesis, thrombosis, inflammation, and energy metabolism through VEGF, ROS and HMGB1 signaling pathways in rats · Junwei He · 2023 · 31 citations · Cited by this paper
  34. Therapeutic effect of Hosta plantaginea (Lam.) Aschers flowers on acute pharyngitis through inhibition of multi-inflammatory pathways in rats · Jiashui Wang · 2023 · 27 citations · Cited by this paper
  35. Therapeutic potential of luteolin in neurodegenerative disorders: targeting Nrf2, NFĸB, MAPK, and JAK-STAT pathways to combat neuroinflammation and apoptosis · Koleshwar Mahto · 2025 · 26 citations · Cited by this paper
  36. Extraction optimization and constituent analysis of total flavonoid from Hosta plantaginea (Lam.) Aschers flowers and its ameliorative effect on chronic prostatitis via inhibition of multiple inflammatory pathways in rats · Li Yang · 2023 · 25 citations · Cited by this paper
  37. Exploring antithrombotic mechanisms and effective constituents of Lagopsis supina using an integrated strategy based on network pharmacology, molecular docking, metabolomics, and experimental verification in rats · Qingcui Zhang · 2024 · 24 citations · Cited by this paper
  38. Natural phenylethanoid glycosides diuretics derived from Lagopsis supina: Biological activity, mechanism, molecular docking, and structure-activity relationship · Li Yang · 2022 · 23 citations · Cited by this paper
  39. Anti-inflammatory constituents isolated from the flowers of Hosta plantaginea via suppression of the NF-κB signaling pathway in LPS-stimulated RAW 264.7 macrophages · Jie-Wei He · 2023 · 23 citations · Cited by this paper

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