Cycloastragenol overcomes trastuzumab resistance in HER2-positive breast cancer by regulating cell cycle and epithelial-mesenchymal transition through EZH2/PTEN/AKT pathway

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY · Published 2026-07-27 · DOI 10.1007/s00210-026-05645-7

Authors (6)

Mingyuan Wu, Fenggang Hou, Zhaoshuo Yang, Zhenfeng Zhu, Yao Wang, Hong Wang

Abstract

PubPorta does not have an abstract for this article yet.

Read the article at the publisher →

Publication details

Year

2026

Citation

Wu, M., Hou, F., Yang, Z., et al. (2026). Cycloastragenol overcomes trastuzumab resistance in HER2-positive breast cancer by regulating cell cycle and epithelial-mesenchymal transition through EZH2/PTEN/AKT pathway. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. https://doi.org/10.1007/s00210-026-05645-7

Related articles

• Trastuzumab Induces Apoptosis and Cell Cycle Arrest in Triple-Negative Breast Cancer, Suggesting Repurposing Potential · Breast Cancer: Basic and Clinical Research · 2024 · Cites or is cited by this article
• Lipid-based nanocarrier-enabled combination therapy for breast cancer: overcoming drug resistance toward precision oncology · NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY · 2026 · Same journal
• Apoptosis-inducing potential of tilorone dihydrochloride in triple-negative breast cancer: in silico and in vitro evidences · NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY · 2026 · Same journal
• EPA-loaded silica nanoemulsions attenuate DEN-induced hepatic fibroinflammation by modulating homocysteine, PKCα/NF-κB, and Nrf2 signaling · NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY · 2026 · Same journal
• Exploring betanin regulatory impact on TGF-β and PI3K/AKT pathways in oral cancer · NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY · 2026 · Same journal
• Myrtenol modulates TWEAK/TLR4–NF-κB, miR-21, PTEN, and ERK-1 expressions and improves behavioral outcomes in a rat glioblastoma model · NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY · 2026 · Same journal
• Protective effects of ginseng against reproductive injury: mechanisms and research progress · NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY · 2026 · Same journal
• Development of citrinin-loaded liposomes and in vitro toxicogenetic evaluation on breast cells · NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY · 2026 · Same journal
• Luteolin alleviates inflammation by inhibiting the PI3K-Akt-FOXO3a pathway · NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY · 2026 · Same journal
• Novel copper–phenothiazine–amino acid complexes exhibit selective anticancer activity via induction of apoptosis and cell cycle arrest in HepG2 cells · NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY · 2026 · Same journal