Research map: Cycloastragenol overcomes trastuzumab resistance in HER2-positive breast cancer by regulating cell cycle and epithelial-mesenchymal transition through EZH2/PTEN/AKT pathway

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  1. Targeting HER2-positive breast cancer: advances and future directions · Sandra M. Swain · 2022 · 1159 citations · Cited by this paper
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  11. The roles of EZH2 in cancer and its inhibitors · Yuankai Liu · 2023 · 147 citations · Cited by this paper
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  13. Trastuzumab deruxtecan in breast cancer · Miguel Martín · 2024 · 95 citations · Cited by this paper
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  15. Cycloastragenol can negate constitutive STAT3 activation and promote paclitaxel-induced apoptosis in human gastric cancer cells · Sun Tae Hwang · 2019 · 78 citations · Cited by this paper
  16. Luteolin alleviates inflammation by inhibiting the PI3K-Akt-FOXO3a pathway · 2026 · Related
  17. PI3K PROTAC overcomes the lapatinib resistance in PIK3CA-mutant HER2 positive breast cancer · Hongyan Zhang · 2024 · 49 citations · Cited by this paper
  18. Novel copper–phenothiazine–amino acid complexes exhibit selective anticancer activity via induction of apoptosis and cell cycle arrest in HepG2 cells · 2026 · Related
  19. Less-well known functions of cyclin/CDK complexes · Nathan Palmer · 2020 · 45 citations · Cited by this paper
  20. High EZH2 Protein Expression Is Associated with Poor Overall Survival in Patients with Luminal A Breast Cancer · Si‐Hyong Jang · 2016 · 43 citations · Cited by this paper
  21. Dual HER2 inhibition: mechanisms of synergy, patient selection, and resistance · Adrienne Gropper Waks · 2024 · 43 citations · Cited by this paper
  22. NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer · Kyrie Pappas · 2021 · 38 citations · Cited by this paper
  23. LncRNA ANRIL promotes multiple myeloma progression and bortezomib resistance by EZH2-mediated epigenetically silencing of PTEN · Lihui Yang · 2021 · 38 citations · Cited by this paper
  24. The PTEN and ATM axis controls the G1/S cell cycle checkpoint and tumorigenesis in HER2-positive breast cancer · Christian Bassi · 2021 · 32 citations · Cited by this paper
  25. Pharmacokinetics, metabolism, and excretion of cycloastragenol, a potent telomerase activator in rats · Pengkai Ma · 2016 · 31 citations · Cited by this paper
  26. Cycloastragenol protects against glucocorticoid‐induced osteogenic differentiation inhibition by activating telomerase · Jiahuan Wu · 2020 · 31 citations · Cited by this paper
  27. The Functions of PCNA in Tumor Stemness and Invasion · Yuanliang Wang · 2022 · 29 citations · Cited by this paper
  28. Cycloastragenol induces apoptosis and protective autophagy through AMPK/ULK1/mTOR axis in human non-small cell lung cancer cell lines · Lihua Zhu · 2024 · 26 citations · Cited by this paper
  29. Inhibition of DPAGT1 suppresses HER2 shedding and trastuzumab resistance in human breast cancer · Muwen Yang · 2023 · 24 citations · Cited by this paper
  30. Antitumor Effect of Cycloastragenol in Colon Cancer Cells via p53 Activation · Doil Park · 2022 · 22 citations · Cited by this paper
  31. Metastatic HER2-Positive Breast Cancer: Is There an Optimal Sequence of Therapy? · Naomi G. Dempsey · 2023 · 20 citations · Cited by this paper
  32. The HSP90 inhibitor HVH-2930 exhibits potent efficacy against trastuzumab-resistant HER2-positive breast cancer · Minsu Park · 2024 · 19 citations · Cited by this paper
  33. Understanding the spectrum of HER2 status in breast cancer: From HER2-positive to ultra-low HER2 · Sana Ahuja · 2024 · 19 citations · Cited by this paper
  34. Updates in Treatment of HER2-positive Metastatic Breast Cancer · Alzira R. M. Avelino · 2024 · 17 citations · Cited by this paper
  35. HER2-Positive Breast Cancer Treatment and Resistance · Jamunarani Veeraraghavan · 2025 · 17 citations · Cited by this paper
  36. Neoadjuvant chemotherapy using nanoparticle albumin-bound paclitaxel plus trastuzumab and pertuzumab followed by epirubicin and cyclophosphamide for operable HER2-positive primary breast cancer: a multicenter phase II clinical trial (PerSeUS-BC04) · Manabu Futamura · 2023 · 13 citations · Cited by this paper
  37. Targeting ITGβ3 to Overcome Trastuzumab Resistance through Epithelial–Mesenchymal Transition Regulation in HER2-Positive Breast Cancer · Asiye Büşra Boz Er · 2024 · 13 citations · Cited by this paper
  38. Galectin‐3 enhances trastuzumab resistance by regulating cancer malignancy and stemness in HER2 ‐positive breast cancer cells · Yuqiu Chen · 2022 · 12 citations · Cited by this paper
  39. H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferase · Dinoop Ravindran Menon · 2023 · 12 citations · Cited by this paper

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