Research map: Chemotype-Dependent Dissociation of Binding Affinity and Functional Potency in Synthetic Cannabinoids

Back to the article

Papers in this map

  1. Signalling bias in new drug discovery: detection, quantification and therapeutic impact · Terry Kenakin · 2012 · 751 citations · Cited by this paper
  2. DSP-2342, a novel 5-hydroxytryptamine 2A/7 receptor antagonist, has therapeutic potential for behavioral and psychological symptoms of dementia · 2026 · Related
  3. Synthetic cannabinoids: Epidemiology, pharmacodynamics, and clinical implications · Marisol S. Castaneto · 2014 · 715 citations · Cited by this paper
  4. Structure-based prediction of muscarinic M1/M3 receptor antagonist activity: Curated dataset and scaffold-aware evaluation · 2026 · Related
  5. Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex · Kaavya Krishna Kumar · 2019 · 457 citations · Cited by this paper
  6. Improving drug delivery to mitigate cisplatin nephrotoxicity · 2026 · Related
  7. Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures · Tian Hua · 2020 · 364 citations · Cited by this paper
  8. Striatal remodeling in Parkinson disease · 2026 · Related
  9. CB1 Receptor Signaling in the Brain: Extracting Specificity from Ubiquity · Arnau Busquets-García · 2017 · 347 citations · Cited by this paper
  10. Preclinical pharmacology of N-pyrrolidino “nitazene” opioids appearing in nonmedical drug markets · 2026 · Related
  11. Synthetic Cannabinoid–Related Illnesses and Deaths · Jordan Trecki · 2015 · 335 citations · Cited by this paper
  12. Modulation of morphine tolerance and dependence by pyrroloquinoline quinone in mice: Insights into mechanistic bridge from N-methyl-D-aspartate receptors-calcium/calmodulin-dependent protein kinase II signaling to oxidative neuroinflammation · 2026 · Related
  13. Synthetic cannabis: A comparison of patterns of use and effect profile with natural cannabis in a large global sample · ADAM R. WINSTOCK · 2013 · 332 citations · Cited by this paper
  14. Comparative analysis of ligand binding affinities and functional profiles at recombinant human β-adrenergic receptor subtypes 1, 2, and 3 · 2026 · Related
  15. Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex · Changrui Xing · 2020 · 257 citations · Cited by this paper
  16. An antidote in arms: A monoclonal antibody intervention to reverse fentanyl-induced respiratory apnea · 2026 · Related
  17. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding · Mie Mie Aung · 2000 · 254 citations · Cited by this paper
  18. Integrating CYP2D6 and MATE1 activities in drug–drug interaction assessment: Insights from newly developed antidepressant drug ammoxetine · 2026 · Related
  19. Effects of Cannabinoids on Neurotransmission · B. Szabó · 2005 · 253 citations · Cited by this paper
  20. Circumvention of acquired resistance to topoisomerase II-targeted anticancer agents in HL-60 leukemia cells by prevention of intronic polyadenylation · 2026 · Related
  21. Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA · Samuel D. Banister · 2015 · 244 citations · Cited by this paper
  22. Moving around the molecule: Relationship between chemical structure and in vivo activity of synthetic cannabinoids · Jenny L. Wiley · 2013 · 204 citations · Cited by this paper
  23. Endocannabinoids Modulate N-Type Calcium Channels and G-Protein-Coupled Inwardly Rectifying Potassium Channels via CB1 Cannabinoid Receptors Heterologously Expressed in Mammalian Neurons · Juan Guo · 2004 · 195 citations · Cited by this paper
  24. Psychosis Associated With Synthetic Cannabinoid Agonists: A Case Series · Donald Hurst · 2011 · 156 citations · Cited by this paper
  25. The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonist New Psychoactive Substances: Evolution · Samuel D. Banister · 2018 · 130 citations · Cited by this paper
  26. Molecular and Behavioral Pharmacological Characterization of Abused Synthetic Cannabinoids MMB- and MDMB-FUBINACA, MN-18, NNEI, CUMYL-PICA, and 5-Fluoro-CUMYL-PICA · Thomas F. Gamage · 2018 · 103 citations · Cited by this paper
  27. Case Series of Synthetic Cannabinoid Intoxication from One Toxicology Center · Kenneth D. Katz · 2016 · 86 citations · Cited by this paper
  28. Enantiospecific Synthesis, Chiral Separation, and Biological Activity of Four Indazole-3-Carboxamide-Type Synthetic Cannabinoid Receptor Agonists and Their Detection in Seized Drug Samples · Lysbeth H. Antonides · 2019 · 75 citations · Cited by this paper
  29. Fentanyl but not Morphine Interacts with Nonopioid Recombinant Human Neurotransmitter Receptors and Transporters · Randy Torralva · 2020 · 73 citations · Cited by this paper
  30. Emergence and properties of spice and bath salts: A medicinal chemistry perspective · Anita H. Lewin · 2013 · 72 citations · Cited by this paper
  31. Intoxication from the novel synthetic cannabinoids AB-PINACA and ADB-PINACA: A case series and review of the literature · Patil Armenian · 2017 · 59 citations · Cited by this paper
  32. Signalling profiles of a structurally diverse panel of synthetic cannabinoid receptor agonists · Monica Patel · 2020 · 58 citations · Cited by this paper
  33. Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB‐4en‐PICA, MDMB‐4en‐PINACA, ADB‐4en‐PINACA, and MMB‐4CN‐BUTINACA using a combination of binding and different CB1 receptor activation assays—Part II: Structure activity relationship assessment via a β‐arrestin recruitment assay · Katharina Elisabeth Grafinger · 2021 · 45 citations · Cited by this paper
  34. Mefloquine and psychotomimetics share neurotransmitter receptor and transporter interactions in vitro · Aaron J. Janowsky · 2014 · 44 citations · Cited by this paper
  35. Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB‐4en‐PICA, MDMB‐4en‐PINACA, ADB‐4en‐PINACA, and MMB‐4CN‐BUTINACA using a combination of binding and different CB1 receptor activation assays: Part I—Synthesis, analytical characterization, and binding affinity for human CB1 receptors · Edward Pike · 2021 · 44 citations · Cited by this paper
  36. Cannabinoid receptor activation potential of the next generation, generic ban evading OXIZID synthetic cannabinoid receptor agonists · Marie H. Deventer · 2022 · 42 citations · Cited by this paper
  37. Evaluation of carboxamide-type synthetic cannabinoids as CB1/CB2 receptor agonists: difference between the enantiomers · Takahiro S. Doi · 2017 · 40 citations · Cited by this paper
  38. Spicing it up - synthetic cannabinoid receptor agonists and psychosis - a systematic review · Melissa Hobbs · 2018 · 32 citations · Cited by this paper
  39. Structure–activity relationships of valine, tert -leucine, and phenylalanine amino acid-derived synthetic cannabinoid receptor agonists related to ADB-BUTINACA, APP-BUTINACA, and ADB-P7AICA · Eric Sparkes · 2021 · 31 citations · Cited by this paper

Source: OpenAlex (CC0)