Research map: The role of ceramides in the pathophysiology of diabetic retinopathy: Mechanisms and Implications for therapeutic strategies

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Papers in this map

  1. Neurodegeneration in diabetic retinopathy: does it really matter? · Rafael Simó · 2018 · 597 citations · Cited by this paper
  2. MicroRNA-451a downregulation in liraglutide-treated individuals with diabetes: A potential cardiovascular protective mechanism · 2024 · Related
  3. Ceramide: A simple sphingolipid with unique biophysical properties · Bruno M. Castro · 2014 · 388 citations · Cited by this paper
  4. Type 1 diabetes mellitus disease burden in high health expenditure countries between 1990 and 2019 · 2023 · Related
  5. The Role of Ceramides in Insulin Resistance · Emilia Sokołowska · 2019 · 314 citations · Cited by this paper
  6. The triglyceride-glucose index and mortality in chronic kidney and cardiovascular disease patients: A cohort study · 2025 · Related
  7. Endothelial Dysfunction in Diabetic Retinopathy · Fu Gui · 2020 · 215 citations · Cited by this paper
  8. Serum albumin-enhanced screening: A triage strategy and predictive model for OGTT in community-managed patients with coronary heart disease · 2026 · Related
  9. The role of anti-vascular endothelial growth factor (anti-VEGF) in the management of proliferative diabetic retinopathy · Yue Zhao · 2018 · 205 citations · Cited by this paper
  10. Relationship between non-O blood groups and microvascular risk in type 2 diabetes · 2026 · Related
  11. VEGF-targeting drugs for the treatment of retinal neovascularization in diabetic retinopathy · Alessandro Arrigo · 2022 · 200 citations · Cited by this paper
  12. Analysis of the diabetic arterial transcriptome to define novel biomarkers of macrovascular disease · 2026 · Related
  13. The neurovascular unit and the pathophysiologic basis of diabetic retinopathy · Thomas W. Gardner · 2016 · 195 citations · Cited by this paper
  14. A novel approach to diabetes-related foot ulcers/disease: First report of bipolar conventional RF lumbar sympathetic block · 2025 · Related
  15. Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway · Chia‐Ling Chen · 2008 · 187 citations · Cited by this paper
  16. Visceral adipose tissue accumulation and risk of organ complications among individuals with type 2 diabetes mellitus: A two-sample Mendelian randomization study · 2025 · Related
  17. Identification of Novel Functional Inhibitors of Acid Sphingomyelinase · Johannes Kornhuber · 2011 · 183 citations · Cited by this paper
  18. Bioinformatics analyses of potential microRNAs and their target genes in myocardial infarction patients with diabetes · 2025 · Related
  19. Global burden of type 1 diabetes in adults aged 65 years and older, 1990-2019: population based study · Kaijie Yang · 2024 · 169 citations · Cited by this paper
  20. Utility of bioelectrical phase angle for cardiovascular risk assessment among individuals with and without diabetes mellitus · 2024 · Related
  21. Activation of the NLRP 3 inflammasome in microglia: the role of ceramide · Hannah Scheiblich · 2017 · 149 citations · Cited by this paper
  22. The Impact of Oxidative Stress on Blood-Retinal Barrier Physiology in Age-Related Macular Degeneration · Annamaria Tisi · 2021 · 147 citations · Cited by this paper
  23. Signal transduction pathways regulating cyclooxygenase‐2 in lipopolysaccharide‐activated primary rat microglia · Ravi Shankar Akundi · 2005 · 145 citations · Cited by this paper
  24. Angiogenic Abnormalities in Diabetes Mellitus: Mechanistic and Clinical Aspects · Gian Paolo Fadini · 2019 · 140 citations · Cited by this paper
  25. Long Noncoding RNA MALAT1 and Regulation of the Antioxidant Defense System in Diabetic Retinopathy · Rakesh Radhakrishnan · 2020 · 140 citations · Cited by this paper
  26. Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis · Benjamin T. Bikman · 2012 · 132 citations · Cited by this paper
  27. Endothelial STAT3 Activation Increases Vascular Leakage Through Downregulating Tight Junction Proteins: Implications for Diabetic Retinopathy · Jang‐Hyuk Yun · 2016 · 131 citations · Cited by this paper
  28. Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo · Leena P. Bharath · 2015 · 127 citations · Cited by this paper
  29. The Role of JNk Signaling Pathway in Obesity-Driven Insulin Resistance · Jia Feng · 2020 · 120 citations · Cited by this paper
  30. The pathophysiological mechanisms underlying diabetic retinopathy · Lindan Wei · 2022 · 116 citations · Cited by this paper
  31. Diabetic retinopathy: Screening, prevention, and treatment · David D. Chong · 2024 · 112 citations · Cited by this paper
  32. Roles of Ceramides and Other Sphingolipids in Immune Cell Function and Inflammation · Sabrin Albeituni · 2019 · 106 citations · Cited by this paper
  33. Blockade of microglial adenosine A2A receptor suppresses elevated pressure‐induced inflammation, oxidative stress, and cell death in retinal cells · Inês Dinis Aires · 2019 · 93 citations · Cited by this paper
  34. Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy · Javad Mohammad Alizadeh · 2023 · 93 citations · Cited by this paper
  35. Protein Kinase D Negatively Regulates Hepatitis C Virus Secretion through Phosphorylation of Oxysterol-binding Protein and Ceramide Transfer Protein · Yutaka Amako · 2011 · 92 citations · Cited by this paper
  36. Cross Talks between Oxidative Stress, Inflammation and Epigenetics in Diabetic Retinopathy · Renu A. Kowluru · 2023 · 92 citations · Cited by this paper
  37. The role of ceramide accumulation in human induced pluripotent stem cell-derived cardiomyocytes on mitochondrial oxidative stress and mitophagy · Mohamed M. Bekhite · 2021 · 87 citations · Cited by this paper
  38. Dyslipidemia, but Not Hyperglycemia, Induces Inflammatory Adhesion Molecules in Human Retinal Vascular Endothelial Cells · Weiqin Chen · 2003 · 82 citations · Cited by this paper
  39. Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis · Amrita Jain · 2016 · 80 citations · Cited by this paper

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