Diabetes & Vascular Disease Research · Published 2026-07-01 · DOI 10.1177/14791641261474101
Fabian O. Lurquin, Elise L. Petit, Philippe Oriot, Sylvie A. Ahn, Michel P. Hermans
Introduction ABO groups impact macroangiopathy risk in T2D. It is unknown whether such modulation extends to microvascular complications. Method Single-centre cross-sectional study including 1,006 T2D patients. Results Prevalence of overall microangiopathy was 51%. No significant differences (ANOVA) were observed between ABO groups in terms of age, sex, diabetes duration, BMI, hypertension, chronic kidney disease or diabetic foot. Insulin sensitivity and the hyperbolic HOMA product [BxS] were lower among non-O groups (-20% and -14%, respectively; p 0.001 and 0.013), while HbA1c and lifetime hyperglycaemia exposure were higher (+5% and +25%, respectively; p 0.006 and 0.002). Overall microangiopathy was more prevalent among non-O patients (+23%; p 0.001), as was neuropathy (+44%; p 0.005). Differences across ABO groups were significant for overall microangiopathy (p 0.009) and neuropathy (p 0.027) (ANOVA). In multivariate analysis, group A (vs O) was associated with overall microangiopathy (OR=1.62; 95%CI: 1.18–2.22; p 0.003) after adjustment for diabetes duration, HbA1c, smoking, remnant-C and hypertension. Conclusion T2D patients of blood group A have increased frequency of overall microangiopathy, regardless of other risk factors. Group O subjects exhibit better glucose homeostasis, with better insulin sensitivity and β-cell function. The ABO system therefore impacts both glucose homeostasis and microvascular susceptibility in T2D.
Abstract from DOAJ. Public domain (CC0 1.0).
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Lurquin, F., Petit, E., Oriot, P., et al. (2026). Relationship between non-O blood groups and microvascular risk in type 2 diabetes. Diabetes & Vascular Disease Research. https://doi.org/10.1177/14791641261474101