Research map: Premature senescence impairs hematopoietic stem cell function during sickle cell disease in mice and humans

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  1. Fiji: an open-source platform for biological-image analysis · Johannes Schindelin · 2012 · 73297 citations · Cited by this paper
  2. Sickle-cell disease linked to prematurely aged stem cells in mice · 2026 · Cites this paper
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  17. Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease · LaTonya J. Hickson · 2019 · 1379 citations · Cited by this paper
  18. Heterogeneous human muscle fibroadipogenic progenitors include a DLK1 + subpopulation that prevents fatty infiltration after injury · 2026 · Related
  19. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age · Derrick J. Rossi · 2007 · 1119 citations · Cited by this paper
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  21. Cellular senescence and senolytics: the path to the clinic · Selim Chaib · 2022 · 1096 citations · Cited by this paper
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  23. A guide to assessing cellular senescence in vitro and in vivo · Estela González‐Gualda · 2020 · 656 citations · Cited by this paper
  24. Phase I Study of Navitoclax (ABT-263), a Novel Bcl-2 Family Inhibitor, in Patients With Small-Cell Lung Cancer and Other Solid Tumors · Leena Gandhi · 2011 · 607 citations · Cited by this paper
  25. Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia · Steven M. Chan · 2015 · 587 citations · Cited by this paper
  26. Sickle Cell Disease · Patricia L. Kavanagh · 2022 · 484 citations · Cited by this paper
  27. Transgenic Knockout Mice with Exclusively Human Sickle Hemoglobin and Sickle Cell Disease · Chris Pászty · 1997 · 476 citations · Cited by this paper
  28. Exagamglogene Autotemcel for Severe Sickle Cell Disease · Haydar Frangoul · 2024 · 472 citations · Cited by this paper
  29. Biologic and Clinical Efficacy of LentiGlobin for Sickle Cell Disease · Julie Kanter · 2021 · 427 citations · Cited by this paper
  30. Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium. · Andreas Leo Petzer · 1996 · 383 citations · Cited by this paper
  31. Correction of sickle cell disease by homologous recombination in embryonic stem cells · Li-Chen Wu · 2006 · 327 citations · Cited by this paper
  32. Inflammation in sickle cell disease · Nicola Conran · 2018 · 296 citations · Cited by this paper
  33. Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice · Tatiana D. Saccon · 2021 · 253 citations · Cited by this paper
  34. Non-apoptotic functions of BCL-2 family proteins · Atan Gross · 2017 · 206 citations · Cited by this paper
  35. Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway · Frédéric Lessard · 2018 · 188 citations · Cited by this paper
  36. Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses · Tanggang Deng · 2018 · 169 citations · Cited by this paper
  37. Genealogies of clones of diploid fibroblasts · P. Marlene Absher · 1974 · 167 citations · Cited by this paper
  38. Perturbation of Ribosome Biogenesis Drives Cells into Senescence through 5S RNP-Mediated p53 Activation · Kazuho Nishimura · 2015 · 167 citations · Cited by this paper
  39. Increased risk of leukemia among sickle cell disease patients in California · Ann M. Brunson · 2017 · 148 citations · Cited by this paper

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