Premature senescence impairs hematopoietic stem cell function during sickle cell disease in mice and humans

Science Translational Medicine · Published 2026-07-22 · DOI 10.1126/scitranslmed.adv0628

Free full text

Authors (21)

Aditya Barve, Preeti Dabas, Adam Cornwell, Pramika Sriram, Alex Kopyov, Mattieu Zhai, Emilia Kooienga, Zakiya Kelley, James Johnson, Jacquelyn A. Myers, Esther A. Obeng, Guolian Kang, Yunusa Olufadi, Terri Cain, Lindsay Talbot, David Spence, Mauricio Cortes, Samuel A. Miller, Dirk Loeffler, Akshay Sharma, Shannon McKinney-Freeman

Abstract

PubPorta does not have an abstract for this article yet.

Read the article at the publisher →

Publication details

Year

2026

Citation

Barve, A., Dabas, P., Cornwell, A., et al. (2026). Premature senescence impairs hematopoietic stem cell function during sickle cell disease in mice and humans. Science Translational Medicine. https://doi.org/10.1126/scitranslmed.adv0628

Related articles

• Sickle-cell disease linked to prematurely aged stem cells in mice · Nature · 2026 · Cites or is cited by this article
• Genetic therapies for the first molecular disease · The Journal of Clinical Investigation · 2025 · Cites or is cited by this article
• Clinical validation of an HPV whole-genome sequencing assay for MRD detection in patients with HPV+ head and neck cancer treated with surgery · Science Translational Medicine · 2026 · Same journal
• Cancer-induced nerve injury unveils a sympathetic-to-sensory nerve axis in a mouse model of head and neck squamous cell carcinoma · Science Translational Medicine · 2026 · Same journal
• KSHV-infected endothelial cells expand and up-regulate angiogenic pathways and CXCR4 in patient-derived Kaposi sarcoma models · Science Translational Medicine · 2026 · Same journal
• PTEN acts as a master mediator of nonhealing venous leg ulcers by suppressing immune response, angiogenesis, and lymphangiogenesis · Science Translational Medicine · 2026 · Same journal
• Glioblastoma: Overcoming fundamental biological and delivery barriers to therapy · Science Translational Medicine · 2026 · Same journal
• Complement augments antibody neutralization of SARS-CoV-2 variants · Science Translational Medicine · 2026 · Same journal
• Engineered antibodies bypass bacterial immune evasion to drive complement-mediated protection against lethal infections · Science Translational Medicine · 2026 · Same journal
• Heterogeneous human muscle fibroadipogenic progenitors include a DLK1 + subpopulation that prevents fatty infiltration after injury · Science Translational Medicine · 2026 · Same journal