Research map: Tumour cell density quantified by artificial intelligence is associated with differential benefit from irinotecan-based chemo-radiotherapy in locally advanced rectal cancer: a post-hoc study of the phase 3 ARISTOTLE trial Back to the article
Papers in this map Tumor microenvironment complexity and therapeutic implications at a glance · Roghayyeh Baghban · 2020 · 1825 citations · Cited by this paperEndogenous neuroprotection in vascular cognitive impairment and dementia · 2026 · RelatedShort-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial · Renu R. Bahadoer · 2020 · 1722 citations · Cited by this paperChronological versus physiological age for 10-year survival estimation: a real-world healthsystem-wide cohort analysis · 2026 · RelatedNeoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial · Thierry Conroy · 2021 · 1366 citations · Cited by this paperMicrocephaly-like phenotype triggered by novel reassortant and prototypic Oropouche virus strains in brain organoids · 2026 · RelatedRectal Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology · Al B. Benson · 2022 · 864 citations · Cited by this paperImmunology of pregnancy and sepsis: shared and specific pathways guiding future precision care · 2026 · RelatedTumor-associated stromal cells as key contributors to the tumor microenvironment · Karen M. Bussard · 2016 · 782 citations · Cited by this paperCardioMorph Atlas: a statistical approach to evaluate association between pulmonary tuberculosis and cardiac morphology from chest X-rays · 2026 · RelatedWhole-Slide Mitosis Detection in H&E Breast Histology Using PHH3 as a Reference to Train Distilled Stain-Invariant Convolutional Networks · David Tellez · 2018 · 296 citations · Cited by this paperData-driven trajectories of atrophy explain clinical heterogeneity across Lewy body diseases · 2026 · RelatedAssociation between tumor-stroma ratio and prognosis in solid tumor patients: a systematic review and meta-analysis · Jiayuan Wu · 2016 · 216 citations · Cited by this paperd-serine as a metabolic immune checkpoint in the tumour microenvironment · 2026 · RelatedThe proportion of tumour cells is an independent predictor for survival in colorectal cancer patients · Nicholas Paul West · 2010 · 194 citations · Cited by this paperLoss of vesicular monoamine transporter 2 in striatum of long COVID and relationship to neuropsychiatric symptoms · 2026 · RelatedScoring the tumor-stroma ratio in colon cancer: procedure and recommendations · Gabi W. van Pelt · 2018 · 193 citations · Cited by this paperIntratumoural plasma cells mediate a pro-inflammatory response to kinase inhibition and successful immune checkpoint blockade therapy in malignant peripheral nerve sheath tumours · 2026 · RelatedArtificial intelligence quantified tumour-stroma ratio is an independent predictor for overall survival in resectable colorectal cancer · Ke Zhao · 2020 · 160 citations · Cited by this paperMulticenter, Randomized, Phase III Trial of Neoadjuvant Chemoradiation With Capecitabine and Irinotecan Guided by UGT1A1 Status in Patients With Locally Advanced Rectal Cancer · Ji Ye Zhu · 2020 · 131 citations · Cited by this paperThe Relationship Between Tumor Budding, Tumor Microenvironment, and Survival in Patients with Primary Operable Colorectal Cancer · Hester Catharina Van Wyk · 2019 · 104 citations · Cited by this paperManagement of Locally Advanced Primary and Recurrent Rectal Cancer · Johannes H.W. de Wilt · 2007 · 63 citations · Cited by this paperDifferential and longitudinal immune gene patterns associated with reprogrammed microenvironment and viral mimicry in response to neoadjuvant radiotherapy in rectal cancer · Anna Clare Wilkins · 2021 · 37 citations · Cited by this paperImpact of Tumor–Stroma Ratio on the Prognosis of Colorectal Cancer: A Systematic Review · Jin‐Lai Gao · 2021 · 34 citations · Cited by this paperTumor Stroma Ratio and Its Significance in Locally Advanced Colorectal Cancer · Luz Sullivan · 2022 · 34 citations · Cited by this paperStandardized Assessment of the Tumor-Stroma Ratio in Colorectal Cancer: Interobserver Validation and Reproducibility of a Potential Prognostic Factor · Ricella Souza da Silva · 2021 · 29 citations · Cited by this paperImage-based consensus molecular subtyping in rectal cancer biopsies and response to neoadjuvant chemoradiotherapy · Maxime W. Lafarge · 2024 · 25 citations · Cited by this paperARISTOTLE: A phase III trial comparing concurrent capecitabine with capecitabine and irinotecan (Ir) chemoradiation as preoperative treatment for MRI-defined locally advanced rectal cancer (LARC). · David Sebag‐Montefiore · 2020 · 24 citations · Cited by this paperThe value of the tumour-stroma ratio for predicting neoadjuvant chemoradiotherapy response in locally advanced rectal cancer: a case control study · Yanting Liang · 2021 · 20 citations · Cited by this paperIdentification and validation of a machine learning model of complete response to radiation in rectal cancer reveals immune infiltrate and TGFβ as key predictors · Enric Domingo · 2024 · 20 citations · Cited by this paperBiopsy proportion of tumour predicts pathological tumour response and benefit from chemotherapy in resectable oesophageal carcinoma: results from the UK MRC OE02 trial · Matthew David Hale · 2016 · 17 citations · Cited by this paperTumour-stroma ratio to predict pathological response to neo-adjuvant treatment in rectal cancer · Maud T. A. Strous · 2022 · 14 citations · Cited by this paperTumour purity assessment with deep learning in colorectal cancer and impact on molecular analysis · Lydia A. Schoenpflug · 2024 · 12 citations · Cited by this paperDeep-learning enabled combined measurement of tumour cell density and tumour infiltrating lymphocyte density as a prognostic biomarker in colorectal cancer · Alice C. Westwood · 2025 · 10 citations · Cited by this paperStratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures · Umair Mahmood · 2024 · 9 citations · Cited by this paperPrognostic Value of Tumor-Stroma Ratio in a Screened Stage II Colon Cancer Population: Intratumoral Site-Specific Assessment and Tumor Budding Synergy · Maria Pihlmann Kristensen · 2025 · 9 citations · Cited by this paperSoftCTM: Cell Detection by Soft Instance Segmentation and Consideration of Cell-Tissue Interaction · Lydia A. Schoenpflug · 2024 · 4 citations · Cited by this paperNeoadjuvant chemoradiotherapy with capecitabine and irinotecan guided by UGT1A1 status in patients with locally advanced rectal cancer: 5‐year update of the CinClare trial · Zhen Zhang · 2025 · 3 citations · Cited by this paperUntitled · Cited by this paper Source: OpenAlex (CC0)