Research map: Glioblastoma: Overcoming fundamental biological and delivery barriers to therapy

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Papers in this map

  1. Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma · Roger Stupp · 2005 · 22129 citations · Cited by this paper
  2. Clinical validation of an HPV whole-genome sequencing assay for MRD detection in patients with HPV+ head and neck cancer treated with surgery · 2026 · Related
  3. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary · David N. Louis · 2021 · 12624 citations · Cited by this paper
  4. Cancer-induced nerve injury unveils a sympathetic-to-sensory nerve axis in a mouse model of head and neck squamous cell carcinoma · 2026 · Related
  5. MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma · Monika E. Hegi · 2005 · 7491 citations · Cited by this paper
  6. KSHV-infected endothelial cells expand and up-regulate angiogenic pathways and CXCR4 in patient-derived Kaposi sarcoma models · 2026 · Related
  7. The Somatic Genomic Landscape of Glioblastoma · Cameron Brennan · 2013 · 5258 citations · Cited by this paper
  8. PTEN acts as a master mediator of nonhealing venous leg ulcers by suppressing immune response, angiogenesis, and lymphangiogenesis · 2026 · Related
  9. Structure and function of the blood–brain barrier · N. Joan Abbott · 2009 · 5204 citations · Cited by this paper
  10. Premature senescence impairs hematopoietic stem cell function during sickle cell disease in mice and humans · 2026 · Related
  11. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival · Michel Lacroix · 2001 · 3121 citations · Cited by this paper
  12. Complement augments antibody neutralization of SARS-CoV-2 variants · 2026 · Related
  13. An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma · Cyril Neftel · 2019 · 3053 citations · Cited by this paper
  14. Engineered antibodies bypass bacterial immune evasion to drive complement-mediated protection against lethal infections · 2026 · Related
  15. PARP inhibitors: Synthetic lethality in the clinic · Christopher J. Lord · 2017 · 2989 citations · Cited by this paper
  16. Heterogeneous human muscle fibroadipogenic progenitors include a DLK1 + subpopulation that prevents fatty infiltration after injury · 2026 · Related
  17. Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma · Roger Stupp · 2017 · 2705 citations · Cited by this paper
  18. Cytokine-mediated activation of kidney-infiltrating CD8 + T cells enables their contribution to inflammation in human lupus nephritis · 2026 · Related
  19. Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma · Olivier Louis Chinot · 2014 · 2573 citations · Cited by this paper
  20. The pyrrolidinamide antimalarial drug MMV367 rapidly clears blood-stage Plasmodium falciparum in healthy adults with experimental malaria · 2026 · Related
  21. EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood · Michael Weller · 2020 · 2073 citations · Cited by this paper
  22. The Microenvironmental Landscape of Brain Tumors · Daniela F. Quail · 2017 · 1963 citations · Cited by this paper
  23. Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy · Christine E. Brown · 2016 · 1881 citations · Cited by this paper
  24. A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma · Donald M. O’Rourke · 2017 · 1838 citations · Cited by this paper
  25. An extent of resection threshold for newly diagnosed glioblastomas · Nader Sanai · 2011 · 1677 citations · Cited by this paper
  26. Noninvasive MR Imaging–guided Focal Opening of the Blood-Brain Barrier in Rabbits · Kullervo H. Hynynen · 2001 · 1483 citations · Cited by this paper
  27. Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial · Derin B. Keskin · 2018 · 1481 citations · Cited by this paper
  28. Convection-enhanced delivery of macromolecules in the brain. · R. Hunt Bobo · 1994 · 1429 citations · Cited by this paper
  29. Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma · Timothy Francis Cloughesy · 2019 · 1429 citations · Cited by this paper
  30. Electrical and synaptic integration of glioma into neural circuits · Humsa S. Venkatesh · 2019 · 1417 citations · Cited by this paper
  31. Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas · Henry Brem · 1995 · 1398 citations · Cited by this paper
  32. A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma · Manfred Westphal · 2003 · 1333 citations · Cited by this paper
  33. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2016—2020 · Quinn T. Ostrom · 2023 · 1309 citations · Cited by this paper
  34. Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial · Annika Malmström · 2012 · 1294 citations · Cited by this paper
  35. Glutamatergic synaptic input to glioma cells drives brain tumour progression · Varun Venkataramani · 2019 · 1241 citations · Cited by this paper
  36. Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma · James Perry · 2017 · 1211 citations · Cited by this paper
  37. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial · Wolfgang Wick · 2012 · 1137 citations · Cited by this paper
  38. Overcoming the blood–brain tumor barrier for effective glioblastoma treatment · Olaf van Tellingen · 2015 · 1054 citations · Cited by this paper
  39. Practice parameter: Anticonvulsant prophylaxis in patients with newly diagnosed brain tumors [RETIRED] · Michael Glantz · 2000 · 862 citations · Cited by this paper

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