Research map: In situ generation of proinflammatory CAR macrophages via mRNA-TLR agonist co-delivery for triple-negative breast cancer immunotherapy

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  1. CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients · Cameron John Turtle · 2016 · 2150 citations · Cited by this paper
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  13. Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens · Geoffrey M. Lynn · 2020 · 346 citations · Cited by this paper
  14. Systemic immune profiling in hepatocellular carcinoma: navigating etiological heterogeneity and selection bias · 2026 · Related
  15. Upregulation of Trop-2 quantitatively stimulates human cancer growth · Marco Trerotola · 2012 · 334 citations · Cited by this paper
  16. Personalized tumor-loaded monocyte-derived dendritic cell vaccination in combination with atezolizumab as maintenance treatment in extensive-stage small cell lung cancer (ES-SCLC): phase Ib-II VENEZOLUNG trial · 2026 · Related
  17. Intracavity generation of glioma stem cell–specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy · Chen Chen · 2022 · 295 citations · Cited by this paper
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  19. Macrophage p38α promotes nutritional steatohepatitis through M1 polarization · Xiang Zhang · 2019 · 209 citations · Cited by this paper
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  21. Targeting macrophages in hematological malignancies: recent advances and future directions · Wei Li · 2022 · 173 citations · Cited by this paper
  22. TLR 7/8 agonist reverses oxaliplatin resistance in colorectal cancer via directing the myeloid-derived suppressor cells to tumoricidal M1-macrophages · Zhipeng Liu · 2019 · 167 citations · Cited by this paper
  23. RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis · Yong‐Hyun Han · 2017 · 156 citations · Cited by this paper
  24. FDA Approval Summary: Accelerated Approval of Sacituzumab Govitecan-hziy for Third-line Treatment of Metastatic Triple-negative Breast Cancer · Sakar Wahby · 2020 · 153 citations · Cited by this paper
  25. Trop2: Jack of All Trades, Master of None · Sára Lénart · 2020 · 147 citations · Cited by this paper
  26. A randomized controlled phase II trial of a novel composition of paclitaxel embedded into neutral and cationic lipids targeting tumor endothelial cells in advanced triple-negative breast cancer (TNBC) · Ahmad Hussein Awada · 2014 · 141 citations · Cited by this paper
  27. Spleen SORT LNP Generated in situ CAR T Cells Extend Survival in a Mouse Model of Lymphoreplete B Cell Lymphoma · Ester Álvarez‐Benedicto · 2023 · 133 citations · Cited by this paper
  28. CAR T cell combination therapies to treat cancer · Uğur Uslu · 2024 · 123 citations · Cited by this paper
  29. Dual mRNA co-delivery for in situ generation of phagocytosis-enhanced CAR macrophages augments hepatocellular carcinoma immunotherapy · Zhenmei Yang · 2023 · 118 citations · Cited by this paper
  30. Lipid nanoparticles outperform electroporation in mRNA-based CAR T cell engineering · Reni Kitte · 2023 · 117 citations · Cited by this paper
  31. mRNA-Laden Lipid-Nanoparticle-Enabled in Situ CAR-Macrophage Engineering for the Eradication of Multidrug-Resistant Bacteria in a Sepsis Mouse Model · Chunwei Tang · 2024 · 93 citations · Cited by this paper
  32. Application of toll-like receptors (TLRs) and their agonists in cancer vaccines and immunotherapy · Samik Chakraborty · 2023 · 91 citations · Cited by this paper
  33. Just eat it: A review of CD47 and SIRP-α antagonism · Bryan T. Oronsky · 2020 · 90 citations · Cited by this paper
  34. Simplified Lipid Nanoparticles for Tissue‐ And Cell‐Targeted mRNA Delivery Facilitate Precision Tumor Therapy in a Lung Metastasis Mouse Model · Yuan Fei · 2024 · 85 citations · Cited by this paper
  35. Chimeric antigen receptor therapy meets mRNA technology · Jiacai Wu · 2023 · 79 citations · Cited by this paper
  36. Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids · Manthan N. Patel · 2025 · 78 citations · Cited by this paper
  37. Targeted Imaging of CD206 Expressing Tumor-Associated M2-like Macrophages Using Mannose-Conjugated Antibiofouling Magnetic Iron Oxide Nanoparticles · Yuancheng Li · 2020 · 67 citations · Cited by this paper
  38. First approval in sight for Novartis' CAR-T therapy after panel vote · Cormac Sheridan · 2017 · 53 citations · Cited by this paper
  39. Lymph-Node-Targeted Cholesterolized TLR7 Agonist Liposomes Provoke a Safe and Durable Antitumor Response · Dandan Wan · 2021 · 48 citations · Cited by this paper

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