Research map: Biomimetic chromatographic descriptors for modeling therapeutic, toxic, and lethal blood concentration endpoints: convergence with conventional physicochemical properties

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  1. Best Practices for QSAR Model Development, Validation, and Exploitation · Alexander Tropsha · 2010 · 2049 citations · Cited by this paper
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  15. Fast Gradient HPLC Method to Determine Compounds Binding to Human Serum Albumin. Relationships with Octanol/Water and Immobilized Artificial Membrane Lipophilicity · Klara Livia Valko · 2003 · 341 citations · Cited by this paper
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  17. Drug Levels: Therapeutic and Toxic Serum/Plasma Concentrations of Common Drugs · Ralf Regenthal · 1999 · 292 citations · Cited by this paper
  18. Biosensing technologies for cannabinoid monitoring in pain management: Current methods, clinical needs, and translational challenges · 2026 · Related
  19. A Collection of Therapeutic, Toxic and Fatal Blood Drug Concentrations in Man · A.H. Stead · 1983 · 190 citations · Cited by this paper
  20. Processing-dependent hepatic risk and benefit of Polygonum Multiflorum Radix: Integrated chemical profiling, in vivo validation and candidate quality control markers · 2026 · Related
  21. Rapid‐Gradient HPLC Method for Measuring Drug Interactions with Immobilized Artificial Membrane: Comparison with Other Lipophilicity Measures · Klara Livia Valko · 2000 · 159 citations · Cited by this paper
  22. Lipophilicity and biomimetic properties measured by HPLC to support drug discovery · Klara Livia Valko · 2016 · 128 citations · Cited by this paper
  23. Lipophilicity and biomimetic properties to support drug discovery · Fotios N. Tsopelas · 2017 · 117 citations · Cited by this paper
  24. Fatal blood and tissue concentrations of more than 200 drugs · Frank Mußhoff · 2004 · 100 citations · Cited by this paper
  25. Determination of Solvation Descriptors for Ionic Species: Hydrogen Bond Acidity and Basicity · Michael H. Abraham · 2004 · 92 citations · Cited by this paper
  26. Binding site for basic drugs on α1‐acid glycoprotein as revealed by chemometric analysis of biochromatographic data · Roman Kaliszan · 1995 · 66 citations · Cited by this paper
  27. Postmortem redistribution of drugs: a literature review · Ghadeer M. M. Abdelaal · 2023 · 47 citations · Cited by this paper
  28. Biomimetic chromatography—A novel application of the chromatographic principles · Klara Livia Valko · 2022 · 43 citations · Cited by this paper
  29. Lipophilic and polar interaction forces between acidic drugs and membrane phospholipids encoded in IAM-HPLC indexes: Their role in membrane partition and relationships with BBB permeation data · Lucia Grumetto · 2012 · 36 citations · Cited by this paper
  30. (Q)SAR Assessment Framework: Guidance for the regulatory assessment of (Quantitative) Structure Activity Relationship models and predictions · OECD · 2023 · 29 citations · Cited by this paper
  31. Structural properties governing drug-plasma protein binding determined by high-performance liquid chromatography method · Sharad Kamble · 2017 · 24 citations · Cited by this paper
  32. Pharmacodynamic principles and target concentration intervention · Nick Holford · 2018 · 24 citations · Cited by this paper
  33. Molecular lipophilicity determination of a huperzine series by HPLC: Comparison of C18 and IAM stationary phases · François Darrouzain · 2006 · 16 citations · Cited by this paper
  34. High-throughput logPo/w determination from UHPLC measurements: Revisiting the chromatographic hydrophobicity index · Xavier Subirats · 2015 · 14 citations · Cited by this paper

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