Oxidative degradation of melatonin in solution and solid-state pharmaceutical blends: HPLC-HRMS/MS degradant characterization, metal-mediated acceleration and EDTA mitigation

Journal of Pharmaceutical and Biomedical Analysis · Published 2026-06-23 · DOI 10.1016/j.jpba.2026.117626

Authors (4)

Airton G. Salles, Rafael L. Coelho, Manoel T. Rodrigues, Bruno B. Guidotti

Abstract

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Publication details

Year

2026

Citation

Salles, A., Coelho, R., Rodrigues, M., et al. (2026). Oxidative degradation of melatonin in solution and solid-state pharmaceutical blends: HPLC-HRMS/MS degradant characterization, metal-mediated acceleration and EDTA mitigation. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2026.117626

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