Research map: Microfragmented Adipose Tissue in Pain Management: Bridging Regenerative Biology and Clinical Therapeutics

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Papers in this map

  1. Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies · Patricia A. Zuk · 2001 · 8040 citations · Cited by this paper
  2. Regenerative Medicine in the Management of Musculoskeletal Pain: Mechanisms, Clinical Applications, and Future Directions · Salah N El-Tallawy · 2026 · Cites this paper
  3. MR-107A-02 in Acute Postoperative Pain Management Following Bunionectomy: Results from a Multicenter, Placebo- and Active-Controlled, Phase 3 Trial · 2026 · Related
  4. Remodelling the extracellular matrix in development and disease · Caroline Bonnans · 2014 · 4502 citations · Cited by this paper
  5. In-Clinic and At-Home Patient Experiences with Closed-Loop Spinal Cord Stimulation: 12-Month Outcomes from the Closed-Loop Australia Randomized Crossover Trial · 2026 · Related
  6. A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs · Mihaela Crisan · 2008 · 4034 citations · Cited by this paper
  7. Machine Learning-Based Prediction for Axial Pain Following Expansive Unilateral Open-Door Laminoplasty: A Retrospective Cohort Study · 2025 · Related
  8. Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity · Alban Latrémolière · 2009 · 3918 citations · Cited by this paper
  9. The Analgesic Effect of Tegileridine in Older Adult Patients After Laparoscopic Abdominal Tumor Surgery: Study Protocol for a Randomized Controlled Trial · 2025 · Related
  10. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis · Mohit Kapoor · 2010 · 2809 citations · Cited by this paper
  11. Real-World Data on the Efficacy of OnabotulinumtoxinA Injections as Prophylactic Treatment for Migraine: A Retrospective Study from Jeddah, Saudi Arabia (2016–2024) · 2025 · Related
  12. Role of cytokines in intervertebral disc degeneration: pain and disc content · Makarand V. Risbud · 2013 · 1825 citations · Cited by this paper
  13. A European Delphi Consensus to Support the Diagnosis, Management, and Appropriate Positioning of Topical Treatments for Postherpetic Neuralgia (PHN) · 2026 · Related
  14. Global, regional, and national burden of low back pain, 1990–2020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021 · Manuela Loureiro Ferreira · 2023 · 1738 citations · Cited by this paper
  15. Immuno-Inflammatory Mechanisms in the Chronification of Pain · 2026 · Related
  16. The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity · Keith Brew · 2010 · 1406 citations · Cited by this paper
  17. Advances in mesenchymal stem cells and their derivatives for promoting peripheral nerve regeneration · 2025 · Related
  18. Pain regulation by non-neuronal cells and inflammation · Ru‐Rong Ji · 2016 · 1364 citations · Cited by this paper
  19. Mesenchymal stem cells as a therapeutic strategy to combat oxidative stress-mediated neuropathic pain · 2025 · Related
  20. Proteases involved in cartilage matrix degradation in osteoarthritis · Linda Troeberg · 2011 · 595 citations · Cited by this paper
  21. Microfragmented adipose tissue in orthopedic regeneration: mechanisms, clinical evidence, and regulatory perspectives · 2026 · Related
  22. Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis · Qichan Hu · 2021 · 492 citations · Cited by this paper
  23. ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis · Priyanka Verma · 2011 · 419 citations · Cited by this paper
  24. Disc in flames: Roles of TNF-α and IL-1β in intervertebral disc degeneration · ZI Johnson · 2015 · 397 citations · Cited by this paper
  25. Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling · Lu Wang · 2017 · 370 citations · Cited by this paper
  26. PDGF in bone formation and regeneration: New insights into a novel mechanism involving MSCs · Arnold I. Caplan · 2011 · 317 citations · Cited by this paper
  27. Roles of reactive oxygen and nitrogen species in pain · Daniela Salvemini · 2011 · 301 citations · Cited by this paper
  28. Facet joint syndrome: from diagnosis to interventional management · Romain Perolat · 2018 · 284 citations · Cited by this paper
  29. Exosomes derived from human adipose mesenchymal stem cells attenuate hypertrophic scar fibrosis by miR-192-5p/IL-17RA/Smad axis · Yan Li · 2021 · 273 citations · Cited by this paper
  30. Mesenchymal stem cell exosomes as a cell-free therapy for nerve injury–induced pain in rats · Sheng‐Jie Shiue · 2018 · 272 citations · Cited by this paper
  31. Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance · Jin Wang · 2022 · 256 citations · Cited by this paper
  32. Adipose Tissue and Mesenchymal Stem Cells: State of the Art and Lipogems® Technology Development · Carlo Tremolada · 2016 · 243 citations · Cited by this paper
  33. Facet joint pain—advances in patient selection and treatment · Steven Paul Cohen · 2012 · 232 citations · Cited by this paper
  34. Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study · Hemant Kumar · 2017 · 223 citations · Cited by this paper
  35. Immunomodulatory Effect of Adipose-Derived Stem Cells: The Cutting Edge of Clinical Application · Simona Ceccarelli · 2020 · 219 citations · Cited by this paper
  36. Intratendinous adipose-derived stromal vascular fraction (SVF) injection provides a safe, efficacious treatment for Achilles tendinopathy: results of a randomized controlled clinical trial at a 6-month follow-up · Federico Giuseppe Usuelli · 2017 · 155 citations · Cited by this paper
  37. Comprehensive Evidence-Based Guidelines for Facet Joint Interventions in the Management of Chronic Spinal Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines · Laxmaiah Manchikanti · 2020 · 145 citations · Cited by this paper
  38. Higher Pericyte Content and Secretory Activity of Microfragmented Human Adipose Tissue Compared to Enzymatically Derived Stromal Vascular Fraction · Bianca Vezzani · 2018 · 143 citations · Cited by this paper
  39. The Effect of Intra-articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis · Damir Hudetz · 2017 · 126 citations · Cited by this paper

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