Pain and Therapy · Published 2025-11-20 · DOI 10.1007/s40122-025-00798-4
Abstract Introduction Postoperative pain management poses unique challenges in older adult patients undergoing laparoscopic abdominal tumor surgery. While morphine remains a standard analgesic option, its use in this population is frequently complicated by adverse effects. Tegileridine represents a potential alternative with distinct pharmacological properties that warrant clinical evaluation. Methods This will be a single-center, randomized, assessor-blinded, active-controlled trial. A total of 66 older adult patients undergoing laparoscopic abdominal tumor surgery will be randomized in a 1:1 ratio to receive either tegileridine (0.1 mg bolus) or morphine (1 mg bolus) via patient-controlled intravenous analgesia. Planned Outcomes The primary endpoint is the incidence of moderate-to-severe movement-related pain (NRS ≥ 4) at 24 h postoperatively. Secondary assessments include pain at rest, requirement for rescue analgesia, safety outcomes, and recovery parameters. Trial Registration Registered at the Chinese Clinical Trial Registry on October 14, 2025. Trial Registration Number: ChiCTR2500110485.
Abstract from DOAJ. Public domain (CC0 1.0).
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