Research map: HIF-1α-centered metabolic reprogramming in osteoarthritis: cell type-specific effects and intercellular crosstalk among chondrocytes, BMSCs, and macrophages

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  1. Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival · Ernestina Schipani · 2001 · 811 citations · Cited by this paper
  2. A review of soluble mediator and cytokine networks linking combination immunotherapy, tumor microenvironment remodeling and skeletal muscle dysfunction · 2026 · Related
  3. The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis · Linli Zheng · 2020 · 755 citations · Cited by this paper
  4. GFI1 as a novel regulator of γδ T cell development and the IL-17/IFN-γ lineage commitment · 2026 · Related
  5. LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis · Manoj Arra · 2020 · 423 citations · Cited by this paper
  6. HIF1α Activates Glycolysis to Suppress Mycobacterium tuberculosis Growth in Mouse Bone Marrow‐Derived Macrophages · 2026 · Related
  7. HIF-1α metabolically controls collagen synthesis and modification in chondrocytes · Steve Stegen · 2019 · 318 citations · Cited by this paper
  8. Acquired immune-mediated thrombotic thrombocytopenic purpura with severe cholestatic liver injury and reversible acute kidney injury after ivonescimab-containing chemoimmunotherapy: a case report and literature review · 2026 · Related
  9. Mesenchymal stem cell-based therapy of osteoarthritis: Current knowledge and future perspectives · Carl Randall Harrell · 2018 · 309 citations · Cited by this paper
  10. Lipoprotein (a) fuels EV71 replication by activating p38 MAPK-autophagy axis · 2026 · Related
  11. HIF-1α controls extracellular matrix synthesis by epiphyseal chondrocytes · David Pfander · 2003 · 263 citations · Cited by this paper
  12. Delivery platforms for in vivo CAR-T engineering · 2026 · Related
  13. Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy · Sunli Hu · 2020 · 237 citations · Cited by this paper
  14. Envafolimab – novel anti-PD-1/PD-L1 antibody in cancer treatment · 2026 · Related
  15. Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling · Kenji Kasuno · 2004 · 228 citations · Cited by this paper
  16. Integrated plasma proteomics identifies HLA-G and osteopontin as circulating biomarkers of resistance to PD-1 inhibitor plus chemotherapy in choriocarcinoma · 2026 · Related
  17. D‐mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF‐2α‐dependent manner · Xueman Zhou · 2021 · 187 citations · Cited by this paper
  18. H3K56 lactylation promotes collagen II synthesis to modulate chondrocyte metabolism in posttraumatic osteoarthritis · 2025 · Related
  19. Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implications · Jinwei Xie · 2021 · 173 citations · Cited by this paper
  20. Just a breath away: considerations for oxygen imbalances in osteoarthritis · 2025 · Related
  21. Bone regeneration in inflammation with aging and cell-based immunomodulatory therapy · Junichi Kushioka · 2023 · 164 citations · Cited by this paper
  22. Inflammatory Fibroblast‐Like Synoviocyte‐Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis · Bin Liu · 2024 · 139 citations · Cited by this paper
  23. Cellular succinate metabolism and signaling in inflammation: implications for therapeutic intervention · Hong Huang · 2024 · 130 citations · Cited by this paper
  24. Interaction of HIF1α and β-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice · Wafa Bouaziz · 2016 · 125 citations · Cited by this paper
  25. Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes · Xuezhong Wang · 2022 · 124 citations · Cited by this paper
  26. The role of HIF proteins in maintaining the metabolic health of the intervertebral disc · Elizabeth S. Silagi · 2021 · 119 citations · Cited by this paper
  27. Nanomedicines Reprogram Synovial Macrophages by Scavenging Nitric Oxide and Silencing CA9 in Progressive Osteoarthritis · Yi Yan · 2023 · 115 citations · Cited by this paper
  28. STING regulates metabolic reprogramming in macrophages via HIF-1α during Brucella infection · Marco Túlio R. Gomes · 2021 · 114 citations · Cited by this paper
  29. Lactate-upregulated NADPH-dependent NOX4 expression via HCAR1/PI3K pathway contributes to ROS-induced osteoarthritis chondrocyte damage · Yifan Huang · 2023 · 108 citations · Cited by this paper
  30. Hypoxia inducible factor-1α is an important regulator of macrophage biology · Bingquan Qiu · 2023 · 107 citations · Cited by this paper
  31. The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels · Anna Louise Miles · 2017 · 100 citations · Cited by this paper
  32. Increased HIF-1α in Knee Osteoarthritis Aggravate Synovial Fibrosis via Fibroblast-Like Synoviocyte Pyroptosis · Li Zhang · 2019 · 91 citations · Cited by this paper
  33. CircRNA-UBE2G1 regulates LPS-induced osteoarthritis through miR-373/HIF-1a axis · Guang Chen · 2020 · 87 citations · Cited by this paper
  34. Cross-talk of inflammation and chondrocyte intracellular metabolism in osteoarthritis · Manoj Arra · 2023 · 87 citations · Cited by this paper
  35. Inflammation Triggers Chondrocyte Ferroptosis in TMJOA via HIF-1α/TFRC · Bo Chen · 2024 · 87 citations · Cited by this paper
  36. Expression of VEGF isoforms by epiphyseal chondrocytes during low-oxygen tension is HIF-1α dependent · Thorsten Cramer · 2004 · 85 citations · Cited by this paper
  37. HIF-1α in Osteoarthritis: From Pathogenesis to Therapeutic Implications · Chu-Yang Zeng · 2022 · 84 citations · Cited by this paper
  38. Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis · Christopher J. Brereton · 2022 · 80 citations · Cited by this paper
  39. m6A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p‒AQP1/ANKH axis · Jia‐Shu Yang · 2021 · 77 citations · Cited by this paper

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