Research map: Apoptosis-inducing potential of tilorone dihydrochloride in triple-negative breast cancer: in silico and in vitro evidences

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  1. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies · Brian David Lehmann · 2011 · 5674 citations · Cited by this paper
  2. Lipid-based nanocarrier-enabled combination therapy for breast cancer: overcoming drug resistance toward precision oncology · 2026 · Related
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  6. Cycloastragenol overcomes trastuzumab resistance in HER2-positive breast cancer by regulating cell cycle and epithelial-mesenchymal transition through EZH2/PTEN/AKT pathway · 2026 · Related
  7. Triple negative breast cancer: Pitfalls and progress · Paola Zagami · 2022 · 848 citations · Cited by this paper
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  9. Mitochondrial apoptosis: killing cancer using the enemy within · Jonathan Lopez · 2015 · 814 citations · Cited by this paper
  10. Reduction of primary tumor growth and metastasis in models of triple-negative breast cancer following tilorone administration via type I interferon signaling · 2026 · Related
  11. Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development · Outi M. H. Salo‐Ahen · 2020 · 670 citations · Cited by this paper
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  13. Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases · Julio C. Morales · 2013 · 627 citations · Cited by this paper
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  15. Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis · Wenzhe Li · 2017 · 464 citations · Cited by this paper
  16. Development of citrinin-loaded liposomes and in vitro toxicogenetic evaluation on breast cells · 2026 · Related
  17. Triple-Negative Breast Cancer: A Brief Review About Epidemiology, Risk Factors, Signaling Pathways, Treatment and Role of Artificial Intelligence · Nahlah Makki Almansour · 2022 · 408 citations · Cited by this paper
  18. Luteolin alleviates inflammation by inhibiting the PI3K-Akt-FOXO3a pathway · 2026 · Related
  19. Optimization of cell viability assays to improve replicability and reproducibility of cancer drug sensitivity screens · Peter Larsson · 2020 · 234 citations · Cited by this paper
  20. Novel copper–phenothiazine–amino acid complexes exhibit selective anticancer activity via induction of apoptosis and cell cycle arrest in HepG2 cells · 2026 · Related
  21. Caspase‐3: A primary target for natural and synthetic compounds for cancer therapy · Poonam Yadav · 2021 · 165 citations · Cited by this paper
  22. Interferon Signaling Is Diminished with Age and Is Associated with Immune Checkpoint Blockade Efficacy in Triple-Negative Breast Cancer · Jaclyn Sceneay · 2019 · 161 citations · Cited by this paper
  23. Curcumin inhibits breast cancer stem cell migration by amplifying the E-cadherin/β-catenin negative feedback loop · Shravanti Mukherjee · 2014 · 150 citations · Cited by this paper
  24. The prodomain of caspase-3 regulates its own removal and caspase activation · Katelyn G. Ponder · 2019 · 142 citations · Cited by this paper
  25. Interferon-beta represses cancer stem cell properties in triple-negative breast cancer · Mary R. Doherty · 2017 · 138 citations · Cited by this paper
  26. PGMD/curcumin nanoparticles for the treatment of breast cancer · Mankamna R. Kumari · 2021 · 127 citations · Cited by this paper
  27. Therapeutic landscape in mutational triple negative breast cancer · Yaqin Shi · 2018 · 126 citations · Cited by this paper
  28. Mammosphere Formation Assay from Human Breast Cancer Tissues and Cell Lines · Ylenia Lombardo · 2015 · 119 citations · Cited by this paper
  29. Curcumin inhibits the invasion and metastasis of triple negative breast cancer via Hedgehog/Gli1 signaling pathway · Mengjie Li · 2021 · 119 citations · Cited by this paper
  30. Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer · Che-Pei Kung · 2020 · 111 citations · Cited by this paper
  31. Resveratrol suppresses migration, invasion and stemness of human breast cancer cells by interfering with tumor-stromal cross-talk · Jinyoung Suh · 2018 · 87 citations · Cited by this paper
  32. Development of a novel and economical agar-based non-adherent three-dimensional culture method for enrichment of cancer stem-like cells · Weijie Gao · 2018 · 83 citations · Cited by this paper
  33. The opposing effects of interferon-beta and oncostatin-M as regulators of cancer stem cell plasticity in triple-negative breast cancer · Mary R. Doherty · 2019 · 83 citations · Cited by this paper
  34. Curcumin Conjugated with PLGA Potentiates Sustainability, Anti-Proliferative Activity and Apoptosis in Human Colon Carcinoma Cells · Bhargav N. Waghela · 2015 · 74 citations · Cited by this paper
  35. Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection · Sean Ekins · 2017 · 72 citations · Cited by this paper
  36. Quercetin protects necrotic insult and promotes apoptosis by attenuating the expression of RAGE and its ligand HMGB1 in human breast adenocarcinoma cells · Suhashini Dhumale · 2015 · 62 citations · Cited by this paper
  37. Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond · Sean Ekins · 2020 · 60 citations · Cited by this paper
  38. Tilorone Hydrochloride: Human Toxicity and Interferon Stimulation · H. E. Kaufman · 1971 · 51 citations · Cited by this paper
  39. Tumor inherent interferon regulators as biomarkers of long-term chemotherapeutic response in TNBC · Natasha K. Brockwell · 2019 · 44 citations · Cited by this paper

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