Research map: Virtual special section: Gut microbiota in drug metabolism

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Papers in this map

  1. Mapping human microbiome drug metabolism by gut bacteria and their genes · Michael Bruce Zimmermann · 2019 · 1179 citations · Cited by this paper
  2. A 3-step static mechanistic modeling approach to predicting transporter- and enzyme-mediated interaction signals of direct oral anticoagulants · 2026 · Related
  3. Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme · Bret D. Wallace · 2010 · 1069 citations · Cited by this paper
  4. Investigation of biomarkers for azole antifungal-induced liver injury using primary human hepatocyte spheroids · 2026 · Related
  5. Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta · Henry J. Haiser · 2013 · 711 citations · Cited by this paper
  6. Physiologically based pharmacokinetic modeling of the unusual kinetics of ketoconazole due to nonlinear liver binding and metabolism in rats · 2026 · Related
  7. An Atlas of β-Glucuronidases in the Human Intestinal Microbiome · Rebecca M. Pollet · 2017 · 293 citations · Cited by this paper
  8. Role of CYP3A5 and CYP3A4 in the metabolism and toxicity of 10-hydroxyl mesaconitine, a new potential toxicity marker of Radix Aconiti Lateralis Preparata (Fuzi), in vitro and in vivo · 2026 · Related
  9. Commensal Gut Bacteria Convert the Immunosuppressant Tacrolimus to Less Potent Metabolites · Yukuang Guo · 2018 · 162 citations · Cited by this paper
  10. Mechanistically resolved prediction of compound hepatotoxicity using primary human liver spheroids—Application to recent real-world cases · 2026 · Related
  11. Gut Microbiome Integration in Drug Discovery and Development of Small Molecules · Patrick Jimonet · 2024 · 19 citations · Cited by this paper
  12. A comprehensive investigation into the effect of bisphenol A on the expression of drug-metabolizing enzymes: Consequences for endogenous metabolites and xenobiotic pharmacokinetics · 2026 · Related
  13. In vitro metabolism of targeted covalent inhibitors and their thiol conjugates by gut microbiome from rats, mice, and humans · Ting‐Jia Gu · 2024 · 7 citations · Cited by this paper
  14. Mechanistic Study on the Species Differences in Metabolism and Excretion Pathways of Ivarmacitinib (SHR0302) between Humans and Rats · 2026 · Related
  15. The impact of progressive chronic kidney disease on hepatic drug metabolism · Emily D. Hartjes · 2025 · 6 citations · Cited by this paper
  16. PSMD2 mediates the degradation of CYP1A2 and promotes the progression of metabolic dysfunction-associated steatohepatitis · 2026 · Related
  17. Discovery of Unprecedented Human Stercobilin Conjugates · Sungjoon Cho · 2024 · 5 citations · Cited by this paper
  18. Diagnostic exogenous probe strategy using ezetimibe-glucuronide effectively identifies metabolic dysfunction–associated steatohepatitis · 2026 · Related
  19. Hydrolysis of O-, N-, and N+-glucuronide metabolites in human feces · Zhoupeng Zhang · 2025 · 4 citations · Cited by this paper
  20. Absorption, metabolism, and excretion of single dose oral [14C]camizestrant in healthy human female participants · 2026 · Related
  21. Characterization of fecal deglucuronidation activity in healthy subjects and in patients treated with fecal microbiota transplantation · Arttu Uoti · 2025 · 2 citations · Cited by this paper
  22. Impact of the gut microbiome on hepatic cytochrome P450 3A4 (CYP3A4) in humanized pregnane X receptor-constitutive androstane receptor-CYP3A4/3A7 mice · Jennifer Liem · 2026 · 2 citations · Cited by this paper
  23. The anti-inflammatory drug celecoxib is metabolized by Pseudomonas aeruginosa CYP107S1 in vitro and in vivo · Sylvie E. Kandel · 2025 · 1 citation · Cited by this paper
  24. Gut microbial resistance and metabolism of selective serotonin reuptake inhibitors drive multidrug resistance and contribute to antidepressant tachyphylaxis · Ming-Che Cheng · 2026 · 1 citation · Cited by this paper

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