Research map: The role of necroptosis as a possible therapeutic target in multiple myeloma: the emerging roles of necroptosis

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  1. Necroptosis, pyroptosis and apoptosis: an intricate game of cell death · Damien Bertheloot · 2021 · 2225 citations · Cited by this paper
  2. In search of dependencies in myeloma, consider IRF2 too · Elisa Taìana · 2026 · Cites this paper
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  10. Multiple myeloma · Niels W.C.J. van de Donk · 2021 · 895 citations · Cited by this paper
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  12. The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs · Tencho Tenev · 2011 · 829 citations · Cited by this paper
  13. Case Report: two cases of idiopathic plasmacytic lymphadenopathy subtype of idiopathic multicentric Castleman disease with xanthelasma palpebrum from a Canadian center · 2026 · Related
  14. The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression · Lena Seifert · 2016 · 631 citations · Cited by this paper
  15. Complications and treatment patterns in patients with non-transfusion-dependent α- and β-thalassemia compared with matched controls: a retrospective observational study using administrative claims data in the United States · 2026 · Related
  16. CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy · Abdel Kareem Azab · 2009 · 430 citations · Cited by this paper
  17. Associations with the quality of life of adult family members or partners (informal carers) of people with leukaemia: results from a cross-sectional online global survey · 2026 · Related
  18. Cancer therapy in the necroptosis era · Zhenyi Su · 2016 · 337 citations · Cited by this paper
  19. Understanding therapy-related AML: genetic insights and emerging strategies for high-risk patients · 2025 · Related
  20. The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis · Michio Onizawa · 2015 · 288 citations · Cited by this paper
  21. The “added value” of enrolling hematological patients in clinical trials: a single-center experience · 2025 · Related
  22. Interleukin-6 Inhibits Fas-Induced Apoptosis and Stress-Activated Protein Kinase Activation in Multiple Myeloma Cells · Dharminder Chauhan · 1997 · 271 citations · Cited by this paper
  23. MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death · Yves Dondelinger · 2017 · 210 citations · Cited by this paper
  24. RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells · Ulrike Höckendorf · 2016 · 207 citations · Cited by this paper
  25. Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy · Heng Yang · 2016 · 191 citations · Cited by this paper
  26. Molecular Insights into the Mechanism of Necroptosis: The Necrosome as a Potential Therapeutic Target · Jing Chen · 2019 · 179 citations · Cited by this paper
  27. Anti-α4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis · Yoshihisa Mori · 2004 · 177 citations · Cited by this paper
  28. The role of necroptosis in cancer: A double-edged sword? · Xia Qin · 2019 · 129 citations · Cited by this paper
  29. PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation · Seung-Won Choi · 2018 · 123 citations · Cited by this paper
  30. Current translational potential and underlying molecular mechanisms of necroptosis · Tamás F. Molnar · 2019 · 108 citations · Cited by this paper
  31. Genetic Factors Underlying the Risk of Thalidomide-Related Neuropathy in Patients With Multiple Myeloma · David C. Johnson · 2011 · 102 citations · Cited by this paper
  32. Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells · Naoko A. Wada · 2014 · 75 citations · Cited by this paper
  33. Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome · Kenta Moriwaki · 2016 · 75 citations · Cited by this paper
  34. Immunogenic cell death in cancer immunotherapy · Minji Choi · 2023 · 74 citations · Cited by this paper
  35. Immunogenic Cell Death in Hematological Malignancy Therapy · Zhaoyun Liu · 2023 · 62 citations · Cited by this paper
  36. Differential effect of pharmacological autonomic blockade on some electrophysiological properties of the human ventricle and atrium. · Wataru Shimizu · 1994 · 52 citations · Cited by this paper
  37. Omega-3 Fatty Acids DHA and EPA Reduce Bortezomib Resistance in Multiple Myeloma Cells by Promoting Glutathione Degradation · Jing Chen · 2021 · 51 citations · Cited by this paper
  38. HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells · Rajesh R. Nair · 2009 · 46 citations · Cited by this paper
  39. The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma · Kanagaraju Ponnusamy · 2021 · 45 citations · Cited by this paper

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