Frontiers in Hematology · Published 2025-09-25 · DOI 10.3389/frhem.2025.1638236
Relapsed or refractory (r/r) nodal T-follicular helper cell lymphoma of the angioimmunoblastic type is a rare disease with a dismal prognosis. This disease usually harbors mutations in epigenetic modifiers. A standard of treatment for an r/r disease is not known. Here, we report real-world data of 11 patients with a median age of 73 years, treated with azacitidine, a hypomethylating agent. Overall survival was 182 days. Five patients died from progressive disease; three were in complete remission after allogeneic stem cell transplantation; two were in complete remission, still receiving azacytidine; and one was under treatment for relapse. The treatment was well-tolerated despite the advanced age, and there was a high burden of comorbidities with a median hematopoietic cell transplantation-specific comorbidity index (HCT-CI) of 5, a score for identifying relevant comorbidities. However, a grade 3 or 4 hematological toxicity occurred in nine patients. Azacitidine may be a suitable treatment option for some patients with r/r nodal T-follicular helper cell lymphoma.
Abstract from DOAJ. Public domain (CC0 1.0).
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