Frontiers in Gastroenterology · Published 2026-07-31 · DOI 10.3389/fgstr.2025.1703551
Rong Xie, Weiwei Zhang, YanningI Mao, Yi Qin, Jiaxu Wang, Qi Luo, Linhua Teng, Jiawen Liu
BackgroundThe clinical role of endoscopic resection in the treatment of exophytic gastric schwannomas measuring ≥3 cm remains controversial owing to technical difficulties and a paucity of evidence.Case presentationA 58-year-old female patient was admitted for treatment after a gastric mass was discovered during routine physical examination. Endoscopic ultrasonography (EUS) revealed a well-demarcated, hypoechoic submucosal tumor measuring 40.9×32.3 mm. The patient subsequently underwent endoscopic submucosal dissection (ESD) under general anesthesia. Histopathological analysis confirmed the diagnosis of gastric schwannoma, with immunohistochemical staining showing strong S-100 protein positivity. The patient had an uneventful recovery with no procedure-related complications, and there has been no evidence of recurrence to date.ConclusionWhile this single-case experience indicates the technical feasibility of ESD for gastric schwannomas >3 cm, larger-scale prospective studies are required to establish its role in clinical practice.
Abstract from DOAJ. Public domain (CC0 1.0).
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Xie, R., Zhang, W., Mao, Y., et al. (2026). Endoscopic submucosal dissection for a large (exceeding 3 cm) exophytic gastric schwannoma with 24-hour intragastric retention: a case report and brief literature review. Frontiers in Gastroenterology. https://doi.org/10.3389/fgstr.2025.1703551